Senior Associate Scientist - Cellular Genomics

About the role

We are seeking a highly motivated senior associate scientist to join the Pfizer Cellular Genomics team within Systems Immunology. The successful candidate will collaborate with multidisciplinary teams across research and therapeutic areas to support the application of next-generation sequencing (NGS) and emerging genomic technologies to drug discovery, translational research, and preclinical development programs.

Responsibilities

• Perform and maintain competency in complex Next Generation Sequencing (NGS) workflows according to established operational procedures, quality standards, and laboratory best practices.
• Execute laboratory activities including sample preparation, tissue dissociation, cell and nuclei isolation, nucleic acid extraction, library preparation, quality control, sequencing, and data generation to ensure high-quality and reproducible results.
• Perform upstream data processing and quality assessment of samples, libraries, sequencing runs, and associated datasets prior to downstream computational analyses.
• Optimize, troubleshoot, validate, and continuously improve NGS library preparation, sequencing workflows, and emerging genomics technologies.
• Serve as a technical resource for genomics technologies, providing guidance on experimental design, platform selection, sample requirements, and data management strategies.
• Contribute to the evaluation, implementation, benchmarking, and validation of new genomics assays, platforms, instrumentation, and workflow improvements.
• Educate and train scientists on genomics technologies, laboratory instrumentation, and best practices; deliver presentations and technical updates as appropriate.
• Stay current with advancements in single-cell genomics, spatial transcriptomics, sequencing technologies, and related molecular biology innovations.
• Draft and maintain experimental plans, validation reports, work instructions, SOPs, and other technical documentation.
• Maintain accurate and compliant ELN records and adhere to Pfizer quality, safety, and data integrity standards.

Qualifications

• Education and Experience: Bachelor's degree in Molecular Biology, Genomics, Biotechnology, Biological Sciences, or a related discipline with 3+ years of relevant experience. Master's degree in Molecular Biology, Genomics, Biotechnology, Biological Sciences, or a related discipline with 0+ years of relevant experience.
• Knowledge, Skills And Abilities: Hands-on experience supporting NGS workflows, including assay development, optimization, troubleshooting, validation, and quality review. Experience working with bulk RNA sequencing, single-cell and single-nucleus RNA sequencing, spatial transcriptomics, targeted sequencing, immune repertoire sequencing, epigenomics assays, or related genomic technologies. Experience with tissue dissociation, cell isolation, nuclei isolation, and preparation of samples for single-cell genomics workflows. Proficiency in DNA and RNA extraction, nucleic acid quantification, quality control assessment, and library preparation methodologies. Familiarity with sequencing platforms and associated quality metrics. Experience with genomics data management and basic bioinformatics workflows is desirable. Strong organizational, communication, and interpersonal skills with the ability to work effectively in a collaborative environment. Demonstrated ability to prioritize multiple projects, manage timelines, and deliver high-quality work. Strong problem-solving skills and commitment to scientific rigor and reproducibility. Self-motivated, adaptable, and eager to learn new technologies and approaches.

Pay

The annual base salary for this position ranges from $68,600.00 to $114,300.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary.

Schedule

This position is a Hybrid role.