Senior Advisor, Molecular Pharmacology

About the role

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions. Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work® in 2026.

We are seeking an experienced, collaborative, and scientifically rigorous Senior Advisor, Molecular Pharmacology to provide scientific leadership, at the Associate Director level, for molecular pharmacology activities supporting neuroscience discovery and development programs.The successful candidate will bring a strong foundation in pharmacology and apply broad scientific expertise to address questions related to compound pharmacology, receptor and target biology, signaling mechanisms, and translation across relevant experimental systems. The ideal candidate will combine deep scientific expertise with curiosity, strategic thinking, and