Scientist - Upregulation

About the role

We are seeking a highly motivated Scientist to join our dynamic and innovative Discovery and Research team focused on developing novel antisense therapies for nano-rare diseases. Reporting to the Associate Director, ASO Strategy Research, the successful candidate will play a key role in advancing novel ASO strategies, conducting mechanism-of-action studies, and contributing to next-generation ASO designs.

Responsibilities

• Execute, troubleshoot and analyze in vitro screening experiments supporting ASO design, optimization, and mechanistic understanding.
• Execute, troubleshoot, and analyze in vitro screening experiments within our pipeline to evaluate potential clinical compounds.
• Work closely with cross-functional teams to ensure smooth communication and alignment, contributing to the strategic advancement of our research goals.
• Plan and conduct molecular and cellular biology experiments to advance our understanding of antisense oligonucleotides.
• Adapt quickly to evolving priorities and provide timely updates and clear communication on research progress.
• Collaborate with internal teams to design and execute experiments that will inform decision-making and drive progress in the development of novel therapeutics.
• Maintain accurate electronic laboratory records, analyze and communicate results, develop reproducible procedures, and collaborate across the team to meet program timelines.

Requirements

• US work authorization is required.
• Bachelor (BSc) or Master’s degree (MSc) or equivalent experience in oligonucleotide research and discovery. 2+ years of industry experience is strongly preferred.
• Drug discovery experience is strongly preferred.
• Demonstrated hands-on proficiency in qPCR, including RNA isolation, cDNA preparation, assay setup, data analysis, and troubleshooting.
• Strong experience with protein analysis techniques, including Western blot and ELISA.
• Experience with molecular cloning, including PCR, primer design, plasmid construction and preparation, bacterial transformation, and sequence verification.
• Experience in culturing and transfecting mammalian cell lines, fibroblasts, and iPSC-derived cells is strongly preferred.
• A proven track record of working in a highly collaborative, team- and mission- oriented environment. Track record of accomplishments, including publications in top-tier scientific journals is preferred.
• Strong experience in performing high-throughput screening assays and data analysis.
• Excellent interpersonal skills, with a proven ability to build and maintain effective working relationships within teams and with external partners.
• Able to manage assignments in a fast-paced, rapidly changing environment.
• Strong ability to collaborate effectively within a team.
• A self-starter with a high level of motivation, and a willingness to take initiative and embrace new challenges.

Benefits

n-Lorem offers a competitive benefits package including medical, dental, vision, 403(b) and four (4) weeks paid vacation.