Scientist/Sr. Scientist, Oligo Biology - In Vitro (REMOTE)

Responsibilities

• Design molecular and cellular biology experiments in close collaboration with internal bioinformatics and chemistry teams to support robust in vitro and in vivo screening campaigns.
• Oversee execution of these assays with CRO.
• Manage external CROs, including experimental design, priority setting, technical oversight, data review, timeline management, and proactive troubleshooting to ensure high-quality, timely project execution.
• Design and optimize siRNAs, ASOs, PMOs, and other novel nucleotide modalities to enhance therapeutic profiles.
• Generate and interpret structure-activity relationships (SAR) to guide lead optimization and candidate selection.
• Maintain thorough technical documentation using Electronic Lab Notebooks (ELNs) and effectively communicate experimental strategies, results, and recommendations to multidisciplinary scientific audiences.
• Actively evaluate emerging technologies and scientific literature to identify innovative approaches that enhance oligonucleotide potency, extrahepatic delivery, durability, and safety.

Requirements

• Ph.D. in biology, pharmaceutical sciences, or related discipline with 0-6 years of relevant industry experience, OR M.S. with 2-8 years of industry experience in oligonucleotide therapeutic development.
• Deep understanding of siRNA and ASO design principles, cellular mechanisms of action, and chemical modification strategies.
• Familiarity with state-of-the-art oligonucleotide delivery technologies, including GalNAc conjugates, lipid conjugates, peptide/antibody-oligonucleotide conjugates (AOCs), or other targeted delivery methods.
• Hands-on experience with mammalian cell culture, diverse transfection methodologies.

Qualifications

• Strong ability to manage multiple projects simultaneously and collaborate seamlessly across cross-functional teams and therapeutic areas.
• Strong communication skills with the ability to present complex scientific concepts to multidisciplinary teams.
• Demonstrated ability to work independently while thriving in a collaborative, fast-paced, and highly interdisciplinary research environment.
• Passion for advancing transformative nucleic acid medicines through innovative chemistry and rigorous scientific execution.

Skills & Attributes

• Strong ability to manage multiple projects simultaneously and collaborate seamlessly across cross-functional teams and therapeutic areas.
• Strong communication skills with the ability to present complex scientific concepts to multidisciplinary teams.
• Demonstrated ability to work independently while thriving in a collaborative, fast-paced, and highly interdisciplinary research environment.
• Passion for advancing transformative nucleic acid medicines through innovative chemistry and rigorous scientific execution.

Benefits

• The anticipated base salary range for this position is $115,000 - $175,000.
• This role may also be eligible for a target annual bonus and equity-based compensation, as well as participation in the company’s benefit programs.
• Actual compensation will depend on several factors, which may include, but are not limited to relevant years of experience, educational background, and geography.

Schedule

• This role is fully remote and applicants can be based anywhere in the United States.

Pay

• The anticipated base salary range for this position is $115,000 - $175,000.