Scientist/Sr Scientist

About the role

We are seeking a motivated Scientist or Senior Scientist in mass spectrometry–based proteomics to join our talented, collaborative team in Thousand Oaks, California. In this vital role, you will generate critical proteomic insights that support target identification, drug discovery, and the advancement of innovative screening technologies. You will contribute across both pipeline advancement and screening-platform innovation by developing, implementing, and continuously improving cutting-edge, high-throughput proteomics workflows. This work includes automated sample preparation, mass spectrometry data acquisition and analysis across diverse assay formats, and the design and optimization of next-generation screening and analytical platforms. The successful candidate will bring strong hands-on expertise in high-throughput mass spectrometry systems, along with a rigorous scientific mindset, sound troubleshooting skills, and an enthusiasm for collaborative drug discovery. Your work will enable innovative screening strategies, accelerate discovery programs, and strengthen proteomics support for the broader pipeline.

Responsibilities

• Design, develop, optimize, and implement high-throughput mass spectrometry–based proteomics workflows and screening platforms to accelerate drug discovery.
• Execute automated sample preparation and LC–MS/MS analyses across a broad range of high-throughput proteomics assays.
• Collaborate closely with therapeutic area, biology and chemistry teams as a technical and scientific subject-matter expert, contributing to data-driven decision-making.
• Analyze and interpret proteomics data to generate insights into mechanism of action, target engagement, selectivity, and other key drug-discovery questions.
• Operate, maintain, troubleshoot, and continuously improve high-throughput mass spectrometry systems and associated analytical workflows.
• Present research findings at internal and external meetings, and clearly communicate experimental plans, results, and analyses to cross-functional teams.
• Maintain accurate, organized, and timely documentation of experiments, protocols, methods, and data analyses.

Basic Qualifications

• Doctorate degree (PhD, PharmD, or MD) with relevant experience; OR Master’s degree and 2 years of directly related experience; OR Bachelor’s degree and 4 years of directly related experience.

Preferred Qualifications

• Doctorate degree in proteomics, chemoproteomics, biochemistry, chemistry, analytical science, or a related discipline.
• Hands-on experience developing, optimizing, and applying mass spectrometry–based proteomics assays and workflows.
• Experience operating and troubleshooting advanced LC–MS/MS platforms, such as Orbitrap-based systems, and analyzing proteomics data.
• Experience with high-throughput sample preparation, miniaturization, and laboratory automation platforms.
• Demonstrated ability to develop, refine, or scale assays, analytical methods, or proteomics platforms.
• Quantitative and computational experience analyzing complex, high-dimensional proteomics datasets.
• Experience working in a biotechnology, pharmaceutical, or drug-discovery research environment is preferred.
• Ability to work effectively in a highly integrated, collaborative team environment; strong organizational, verbal, and written communication skills; and a demonstrated commitment to generating reliable, reproducible results.

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan.
• Stock-based long-term incentives.
• Award-winning time-off plans.
• Flexible work models where possible.

Pay

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities.