Scientist - Metabolomics/Lipidomics

About the role

The Metabolomics/Lipidomics Scientist will have extensive experience in metabolite and/or small molecule analysis using LC/MS and LC/MS/MS platforms. The scientist will perform targeted and nontargeted bioanalysis and develop novel methods to support the platform.

Responsibilities

• Conceptualize, perform, analyze, and report experiments.
• Perform mass spectrometry-based assays and studies focused on metabolite analysis of diverse samples from biological matrices.
• Conduct laboratory analytical instrumentation routine maintenance.
• Perform daily QA/QC, system suitability testing, method development, and validated SOP implementation.
• Develop SOPs.
• Manage external collaborations.
• Other duties, as assigned.

Qualifications

• Ph.D. (with 1+ years of experience) in analytical chemistry, biochemistry, or a related field in the analysis of small molecules and metabolites by mass spectrometry.
• Broad understanding of metabolomics/lipidomics applications and biochemistry in the areas of systems biology, neurodegeneration, obesity, cardiovascular disease, and cancer is a plus.
• Proven ability to troubleshoot common instrumentation-related issues, specifically for HPLC and MS systems.
• Experience with common sample preparation techniques, including solid phase extraction (SPE), liquid-liquid extraction, and protein precipitation for biofluids, tissues, and cells.
• Deep understanding of core HPLC and MS concepts, including (but not limited to) principles of reversed-phase LC and HILIC, high-resolution/accurate mass strategies, structural elucidation by MS/MS, isotope dilution, isotopologue identification, and multiple-charged ions.
• Excellent communication and interpersonal skills combined with a proven track record of technical and organizational skills.
• Must be able to work in a team-oriented environment and demonstrate attention to detail and record-keeping.
• Must demonstrate a fully professional level requiring independent work in metabolomics research and development.
• Knowledge of Microsoft Word, Excel, and PowerPoint required for preparation of reports to management.
• Ability to prepare manuscripts for presentation, publication in scientific journals, and regulatory requirements is preferred.