Scientist, Membrane Protein Biochemistry

At Amgen, our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With a focus on Oncology, Inflammation, General Medicine, and Rare Disease, we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity-related conditions. Join us and transform the lives of patients while transforming your career.

About the role

In this vital role, you will design strategies for recombinant production of polytopic membrane protein (MP) targets and purify MPs into stable formulations with detailed analytical characterization. This role will also include opportunities to develop capabilities that increase the success rates of large-molecule and small-molecule therapeutic discovery programs. This is an onsite laboratory position at our South San Francisco site.

Responsibilities

• Independently devise and implement state-of-the-art membrane protein production strategies through conducting laboratory experiments with rigorous documentation and emphasis on quality of deliverables
• Analyze and interpret scientific data with the intent to communicate results to audiences with diverse scientific backgrounds
• Collaborate with other scientists to plan methodological approaches, necessary resources, timelines, and milestones to drive defined projects forward
• Keep current in membrane protein expertise to advise supervisors and colleagues on future membrane protein technology development strategies

Qualifications

Basic Qualifications

• Ph.D. in Biochemistry, Biophysics, Chemistry, Molecular Biology, or a related discipline
• OR Master’s degree and 2 years of relevant laboratory experience
• OR Bachelor’s degree and 4 years of relevant laboratory experience

Preferred Qualifications

• Ph.D. plus 0-2 years of relevant postdoctoral experience
• Demonstration of independent design, execution, and interpretation of experiments and results, as exemplified by a solid publication record with first-author publication(s)
• Proven expertise with ÄKTA systems and analytical methods for membrane protein characterization using quality-focused analytical methods such as HPLC/UPLC (SEC, fSEC), spectroscopy, or mass spectrometry
• Proven expertise in structural biology or dissection of MP molecular pharmacology is a plus
• Excellent communication skills (both written and oral), leadership skills, and the ability to work well in teams in a fast-paced environment

Benefits

From our competitive benefits to our collaborative culture, we support your professional and personal growth and well-being. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible