Scientist - In Vivo Molecular Neurotechnology

About the role

In this role, you will:

• Own and scale in vivo validation pipelines in rodents for molecular biosensors/actuators, including gene delivery, surgical workflows, sensory/behavioral paradigms, and ex vivo characterization.
• Optimize delivery vehicles, administration methods and parameters for robust, cell-type specific expression, and quantify the outcomes at the functional and molecular scale.
• Design and perform in vivo experiments to benchmark functional performance of biosensors/actuators in physiologically relevant neuroscience context.
• Collaborate with hardware engineers and platform teams to develop and build custom setup incorporating novel imaging and modulation instruments.
• Assess tolerability and biological effects through functional and molecular assays, and identify practical levers that improve long-term tolerability while maintaining function.
• Work closely with molecular engineers, physical engineers and data scientists to define project goals, solve problems and come up with new ideas.

Requirements

You might thrive in this role if you:

• Have a PhD in Neuroscience, Biology, Bioengineering or a related field, or have equivalent experience leading research projects end-to-end.
• Have expertise in benchmarking and optimizing molecular tools in vivo, including viral delivery methods, advanced surgical procedures, histology, tissue clearing or expansion microscopy.
• Have experience in in vivo neuroscience research in rodents using sensory or behavioral experiments with simultaneous imaging and/or stimulation.
• Love developing, implementing and troubleshooting novel techniques when they’re very new and there are many things to figure out.
• Enjoy working with multidisciplinary teams, collaborating and communicating with experts across disciplines.
• Are energized by a fast-paced environment with a high sense of mission and urgency.

Qualifications

Nice to have

• Experience in generating transgenic animals.
• Experience with ex vivo methods such as activity-based labeling or spatial sequencing.
• Knowledge and experience in system neuroscience.
• Hands-on or CRO experience with larger animals.
• Experience with protein or gene construct engineering and/or computational approaches.