Scientist-II Developability & Preformulation

The Importance of the Role

The Early Research and Process Development (ERPD) group is seeking a Scientist II with experience in biologics preformulation and developability assessment, with a focus on proteins, antibodies, and antibody-oligonucleotide conjugates (AOCs).

This individual will support the assessment of developability for lead molecules through comprehensive evaluations, including biophysical characterization, forced degradation, and short-term, long-term, and in-use stability studies.

The successful candidate will leverage high-throughput formulation tools and workflows to characterize product stability across a broad range of conditions, including process buffers, excipients, concentrations, hold times, and temperatures.

In collaboration with Analytical Development, the candidate will help define quality attributes and implement stability-indicating assays appropriate for early-stage programs.

The Scientist II will also consider route-of-administration factors, such as subcutaneous delivery, during early formulation assessments (e.g., stability and viscosity at high concentrations, potential enabling approaches).

This role requires strong cross-functional engagement, working closely with Upstream and Downstream Process Development, High-Throughput Automation, and CMC Drug Substance/Drug Product teams to foster a collaborative environment that enables the advancement of robust and scalable manufacturing processes.

The Scientist II will contribute formulation recommendations to research, pilot-scale, and commercial-scale manufacturing groups and generate scientifically rigorous data packages to inform preclinical and early clinical development and enable downstream CMC strategy for Sarepta’s genetic therapy engine.

What Sarepta Offers

• Career opportunities in a dynamic and innovative environment
• A supportive and inclusive workplace culture
• A range of benefits and work-life resources designed to support employees in various aspects of their lives
• Comprehensive benefits package available on the company's website

More About You

• Education: Degree in Biochemistry, Biochemical Engineering, Bioengineering, or Chemical Engineering, or a Ph.D. with 3-5 years or M.S. with 6-8 years of biologics formulation experience
• Experience: Experience with biologics formulation (e.g., mAbs), experience with AOCs or ADCs formulation, hands-on experience with protein formulation technologies, experience with stability and analytical assays to monitor product quality, experience with high-concentration formulation challenges, experience applying Design of Experiments (DoE) principles to formulation development, demonstrated ability to work effectively in cross-functional teams, proficiency in statistical or data analysis tools, prior experience in therapeutic protein discovery or biochemistry research, excellent written and verbal communication skills

What Now?

We’re always looking for solution-oriented, critical thinkers. So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.

This position requires work on site at one of Sarepta’s facilities in the United States.

The targeted salary range for this position is $106,400 - $133,000 per year.

Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.