Scientist II, Assay Operations, Screening Platform Technologies

About the role

As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

Responsibilities

• Optimize, productionalize, validate, and execute robust screening assays across various cellular screening formats (e.g., CellTiter-Glo, NanoBRET, imaging-based, and transcriptomic readouts).
• Lead and support execution of high-throughput and medium-throughput screening campaigns using automated liquid handling and integrated instrumentation platforms.
• Carefully coordinate assay transfer activities internally and externally, including protocol standardization, reagent qualification, documentation, and execution support.
• Develop and implement workflows for quantitative, scalable profiling in support of oncology programs.
• Contribute to experimental design discussions and data review for projects involving molecular glue characterization and protein interaction modulation.
• Apply advanced data analysis methods, integrating tools such as Genedata Screener, D360, Spotfire, and programming languages (Python, R) to derive actionable insights from complex assay outputs.
• Collaborate within SPT and across functions, Med Chem, Cancer Biology, Bioinformatics, Automation, to ensure cohesive project execution and data flow.
• Manage timelines and deliverables for multiple projects simultaneously, maintaining high standards for scientific rigor and project communication.
• Support training and mentorship of junior team members while contributing to the collaborative and mission-driven culture of SPT.

Requirements

• PhD in biological sciences, chemical biology, pharmacology, or bioengineering with 2–4 years of relevant experience; or MS with 5–8 years of experience in industry or biotech settings.
• Demonstrated expertise in assay development and optimization for high-throughput and/or high-content screening platforms.
• Working knowledge of assay performance metrics and screening QC parameters (Z’, signal/background, CVs, normalization strategies).
• Proficiency with data analysis and visualization tools such as Genedata Screener, Spotfire, D360, Excel, or related platforms for large complex data sets.
• Robust experience with cell based assay development and cell based or phenotypic screening.
• Hands-on experience using automation platforms (e.g., Hamilton, Dragonfly, Echo, Mosquito) and familiarity with scheduling software for walk-up and integrated systems.
• Prominent ability to manage and coordinate external CRO partnerships for assay execution and data delivery.
• Excellent organizational and project management skills with the ability to prioritize and balance multiple efforts concurrently.
• Experience supporting phenotypic, mechanistic, or oncology-focused screening assays.
• Excellent communication skills with a collaborative, team-oriented mindset and a strong sense of scientific ownership.

Qualifications

• Familiarity with automated liquid handling (SPT Dragonfly and/or Mosquito, Agilent Bravo, Tecan) is preferred.
• Experience with high throughput screening and comfortabiity leveraging automation and AI/ML to support is preferred.
• Facile with instrumentation, able to troubleshoot problems and work with engineers to generate successful solutions to technical limitations is preferred.
• Rigorous, quantitative, detail-oriented experimentalist with an understanding of statistics is preferred.

Skills

• Deeply analytical and curious—excited by data-driven discovery and uncovering patterns in complex biological systems.
• Energized by working at the interface of technology and biology to solve challenging problems in oncology drug discovery.
• Proactive and adaptable—able to thrive in a fast-paced, evolving environment with high expectations for quality and impact.
• Committed to mentorship, collaboration, and scientific excellence in pursuit of transformative therapies for patients.