Scientist I, TCR-T Engineering and Translation

Location: Upper East Side | Org Unit: MCC Laboratories | Weekly Hours: 35.00 | Exemption Status: Exempt

About the role

Supports the development of next-generation T cell receptor (TCR)-engineered T cell therapies by preparing engineered TCR-T cells and testing their biological properties. This role reports to the Assistant Lead and works collaboratively with the broader team to deliver IND ready candidates for the clinic.

Responsibilities

• Support IND enabling preclinical studies for TCR-T cell programs.
• Generate engineered TCR-transduced T cells using molecular and genomic technologies/platforms.
• Perform cell-based function assays examining biological properties in vitro.
• Assist in testing potency of TCR-T cells in tumor models in vivo.
• Analyze experimental data, prepare summaries, and present findings at team meetings.
• Maintain accurate and detailed record keeping of experimental methods and results in laboratory notebooks; write SOPs.
• As needed, assist in training researchers and laboratory staff in equipment use and experimental techniques.
• Operate with highest integrity and ethics, conduct all experiments following lab, department, and college policies and procedures.
• Collaborate cross-functionally with teams including TCR discovery and vector development.
• Stay current with literature and emerging technologies in the field.
• Contribute to writing of scientific posters and/or manuscripts.
• Perform other related duties as assigned.

Requirements

• Bachelor's Degree in Biology, Biochemistry or related field.
• Minimum 8+ years research experience in an academic laboratory or in the biotechnology or pharmaceutical industry.
• Prior experience in manipulating and culturing human T cells, T cell engineering, molecular and cell biology techniques, conduct and analysis methods in adoptive T cell therapy using mouse tumor models.

Skills

• Highly collaborative, ability to multitask and work cross-functionally.
• Strong organizational skills with the ability to pay close attention to detail.
• Excellent written and verbal communication skills.

Working Conditions

Standard laboratory conditions; may require standing or sitting for long periods of time; may require working within Biologic Safety Level 1 and 2.

Pay

Salary range: $70,200.00 - $83,200.00 (as required under NYC Human Rights Law Int 1208-2018 for NYC offices).

Schedule

Weekly hours: 35.00; Exempt position.