Scientist I, Standardized Organoid Modeling Lab

Job ID: req4574 Employee Type: exempt full-time Division: Laboratory Animal Science Program Facility: Frederick: Ft Detrick Location: PO Box B, Frederick, MD 21702 USA The Frederick National Laboratory is operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases. Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way. Program Description The Laboratory Animal Sciences Program (LASP) provides exceptional quality animal care and technical support services for animal research performed at the National Cancer Institute at the Frederick National Laboratory for Cancer Research. LASP executes this mission by providing a broad spectrum of state-of-the-art technologies and services that are focused on the design, generation, characterization, and application of genetically engineered and biological animal models of human disease, which are aimed at the development of targeted diagnostics and therapies. LASP contributes to advancing human health, developing new treatments, and improving existing treatments for cancer and other diseases while ensuring safe and humane treatment of animals Key Roles/Responsibilities Designing CRISPR-mediated experiments which include, but not limited to, gene knockouts, gene knock-ins, custom targeted libraries and apply these to both organoids and induced pluripotent stem cells (iPSCs)Interfacing with the collaborating investigators from the Standardized Organoid Modeling (SOM) center – providing guidance, consultation, and responding to queries in a timely mannerAssisting the laboratory director in project management and generating activity reportsPerforming CRISPR-mediated experiments in organoid and other 3D culture modelsIllumina-based targeted amplicon sequencingCloning plasmid constructs when neededContributing to manuscripts from both projects led by the GMC as well as supported by the GMC Basic Qualifications To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below: Possession of a PhD or an MD degree from an accredited college or university according to the Council for Higher Education Accreditation. Foreign degrees must be evaluated for U.S. equivalency No work experience required with a PhDExpertise in the generating, culturing and maintaining organoidsExpertise in computer-based data acquisition, management, and data analysisAbility to plan, conduct, troubleshoot, and optimize scientific experimentsExtensive communication and presentation skills, ability to prepare comprehensive informative project documentation and other written deliverables, such as manuscripts, meeting abstracts, etc. Strong track record in research accomplishments e.g. in the form of significant publications in peer-reviewed journals, meeting poster presentations, invited talks, and other evidence of scientific achievementsAbility to obtain and maintain a security clearance Preferred Qualifications Candidates with these desired skills will be given preferential consideration: Expertise in the CRISPR/Cas9 technology as well as general molecular biologySoftware programming and development in pythonExperience running scripts and code on a high-performance computing (HPC) platformWell-developed self-organization, project planning and time management skills JOB HAZARDS This position is subject to working with or has the potential for exposure to infectious material, requiring medical clearance and immunizations Commitment to Non-Discrimination All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, color, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories consistent with relevant laws. Pay And Benefits Pay and benefits are fundamental to any career decision. That's why we craft compensation packages that reflect the importance of the work we do for our customers. Employment benefits include competitive compensation, Health and Wellness programs, Income Protection, Paid Leave and Retirement. More details are available here 93,800.00 - 134,285.00 USD The posted pay range for this job is a general guideline and not a guarantee of compensation or salary. Additional factors considered in extending an offer include, but are not limited to, responsibilities of the job, education, experience, knowledge, skills, and abilities as well as internal equity, and alignment with market data. The salary range posted is a full-time equivalent salary and will vary depending on scheduled hours for part time positions