Scientist I, Medicinal Chemistry

About the role

Join Nurix's medicinal chemistry group to design and synthesize novel small molecules for patients with unmet medical needs. You'll apply structure-based drug design, supported by our computational and structural biology teams, as part of a dynamic, multidisciplinary project team. Location: Onsite – The Woodlands, TX

Responsibilities

• Design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics, and in vivo efficacy, using modern synthetic methods and creative strategies to access challenging molecules
• Engage in rational structure-based drug discovery enabled by our computational and structural biology group
• Apply strong problem-solving skills to troubleshoot challenges and identify practical solutions
• Design and execute high-quality experiments, critically analyze results, and use data to form hypotheses and guide next steps
• Advance structure-activity relationship (SAR) studies by contributing to compound design
• Collaborate with scientists in computational chemistry, structural biology, biochemistry and biophysics, cellular biology, pharmacology, DMPK, and toxicology, as well as external collaborators, to integrate multidisciplinary data and advance project objectives
• Stay current with advances in synthetic and medicinal chemistry and apply relevant methods to project work
• Communicate scientific rationale, results, challenges, and recommendations clearly to chemistry colleagues and cross-functional project teams

Qualifications

• PhD with up to 4 years of relevant experience, MS with 6 or more years of relevant experience, or BS or equivalent with 10 or more years of relevant experience

Skills

• Strong expertise in synthetic organic chemistry, with demonstrated ability to design and execute complex, multistep organic synthesis
• Strong scientific and synthetic problem-solving skills and the ability to independently troubleshoot challenging chemistry
• Scientific curiosity, creativity, and the ability to rapidly learn and apply new concepts, technologies, and approaches
• Strong interpersonal and teamwork skills, with demonstrated ability to contribute in a collaborative, multidisciplinary research environment
• Excellent written and verbal communication skills, with the ability to clearly communicate scientific concepts, results, and conclusions
• Knowledge of medicinal chemistry principles, structure-based drug design, pharmacology, and/or ADME/PK, consistent with prior experience

Pay

Salary Range: $130,200 - $141,400