Scientist I, DTD

About the role

Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases. We are seeking a highly motivated and scientifically rigorous Scientist I to join our Discovery and Translational Development team.

Responsibilities

• Support the scientific execution of preclinical and clinical-stage programs in rare neuromuscular and cardiovascular diseases.
• Design, coordinate, and interpret studies that inform program strategy, candidate selection, mechanism of action, translational biomarkers, dose selection, and clinical development.
• Collaborate cross-functionally with platform, research, clinical, regulatory, bioanalytical, CMC, pharmacology, toxicology, and program management teams.
• Analyze and synthesize complex datasets across in vitro, in vivo, translational, and clinical studies.
• Contribute to experimental strategy for AAV gene therapy and other genomic medicine approaches, including vector biology, tissue targeting, expression, efficacy, safety, immunology, and translational relevance.
• Identify and resolve scientific and technical challenges that arise during program execution.
• Prepare high-quality scientific summaries, presentations, study reports, and decision-making materials for internal governance forums.
• Engage with external collaborators, CROs, academic investigators, and scientific advisors as needed.
• Stay current with advances in gene therapy, genomic medicines, rare disease biology, translational biomarkers, and competitive programs.
• Operate with scientific curiosity, urgency, accountability, and a strong commitment to developing meaningful therapies for patients.

Qualifications

• PhD in molecular biology, genetics, cell biology, pharmacology, neuroscience, cardiovascular biology, muscle biology, or a related discipline and 0-2+ years of relevant postdoctoral, industry, or translational research experience preferred; or equivalent experience in biotechnology, pharmaceutical, or translational research settings.
• Experience with gene therapy, AAV biology, genomic medicines, RNA-based therapeutics, genetic disease, or related therapeutic platforms strongly preferred.
• Strong understanding of preclinical study design, translational biology, and the use of disease models to support therapeutic development.
• Experience in neuromuscular disease, cardiomyopathy, rare disease, or genetic medicine is highly desirable.
• Ability to critically evaluate complex scientific data and translate findings into clear recommendations.
• Strong written and verbal communication skills, with the ability to present scientific concepts clearly to technical and cross-functional audiences.
• Demonstrated ability to work collaboratively in a matrixed, fast-paced environment.
• High level of ownership, intellectual curiosity, adaptability, and scientific judgment.
• Comfortable navigating ambiguity and contributing to decisions when data are evolving or incomplete.

Preferred Experience

• Experience supporting programs from discovery through IND-enabling studies or early clinical development.
• Familiarity with translational biomarkers, biodistribution, pharmacology, toxicology, immunogenicity, and clinical assay strategies.
• Experience working with CROs, academic collaborators, or external scientific partners.
• Familiarity with regulatory-enabling datasets for genetic medicine programs.
• Experience preparing scientific materials for internal governance, regulatory interactions, investor-facing materials, or external scientific presentations.

Core Competencies

• Scientific rigor and critical thinking
• Strong problem-solving skills and ability to think quickly
• Data-driven decision-making
• Clear and concise communication
• Cross-functional collaboration
• Ownership and accountability
• Adaptability in a fast-moving environment
• Passion for rare disease and patient impact

Pay

The base compensation range for this role is: $125,000.00 – 140,000.00 Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Benefits and Solid Advantages

• Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs
• 401(k) program participation with competitive company matched contributions
• Eligibility to participate in Solid’s Employee Stock Purchase Plan
• Mobile phone subsidy for eligible employees
• Tuition Reimbursement
• Vision Coverage
• Life Insurance
• Voluntary Pet Insurance
• Employee Discount Program on Travel, Entertainment, and Services
• Employee Assistance Programs
• Daily Subsidized Lunch Delivery (onsite @ Hood Park)
• Free Onsite Full-Service Gym (onsite @ Hood Park)
• Employee Parking (onsite @ Hood Park)
• 12 Observed Holidays and a winter shut down
• 15-day PTO Policy and an 80-hour rollover YoY
• 40-hour Sick Policy
• 8 Hour Floating Holiday