Scientist I, Discovery Chemistry

About the role

Arrowhead Pharmaceuticals is seeking a highly motivated Scientist I to join our Discovery Chemistry team in San Diego. This role will focus on the design, synthesis, purification, and characterization of peptides that support the discovery and optimization of next-generation RNAi therapeutics. Working as part of a multidisciplinary discovery team, you will leverage your expertise in peptide chemistry to advance innovative drug discovery programs.

Responsibilities

• Design, execute, optimize, and troubleshoot solid-phase peptide synthesis (SPPS) workflows using both automated and manual synthesis techniques.
• Purify and characterize peptides using chromatographic and mass spectrometry techniques, including HPLC and LC-MS.
• Analyze experimental data, interpret results, and propose next steps to support discovery programs.
• Contribute to the design and optimization of novel peptide constructs that support RNAi therapeutic development.
• Maintain accurate and well-organized experimental records using electronic laboratory notebooks (ELNs).
• Present scientific findings and participate in project team discussions.
• Maintain laboratory equipment and ensure compliance with laboratory safety procedures and company policies.
• Stay current with emerging technologies and scientific literature in peptide chemistry and drug discovery.

Requirements

• Bachelor's or Master's degree in Chemistry, Biochemistry, or a related scientific discipline.
• 8+ years of relevant industry laboratory experience or demonstrated scientific leadership within peptide chemistry.
• Strong background in organic chemistry and analytical chemistry.
• Hands-on experience with solid-phase peptide synthesis (SPPS).
• Experience operating automated peptide synthesizers.
• Proficiency in analytical characterization using HPLC, UPLC, and LC-MS.
• Excellent experimental design, troubleshooting, and problem-solving skills.
• Strong written and verbal communication skills with the ability to effectively present scientific results.

Preferred

• Experience supporting peptide discovery from hit identification through lead optimization.
• Experience with high-throughput peptide synthesis or screening technologies.
• Familiarity with biophysical assays used to characterize biomolecular interactions.
• Experience working on oligonucleotide, peptide, or RNA-based therapeutic discovery programs.
• Demonstrated ability to work independently while contributing effectively to cross-functional research teams.

This role is onsite 5 days a week in San Diego.

Pay

$105,000-$115,000 USD