Scientist - Ensemble Structural Informatics

12 hours ago Salary: 100K - 180K Emeryville HQ Onsite Full Time Research Jobs by Astera Institute Astera Institute Visit Astera Institute website A 501(c)(3) science-and-technology research institute/foundation operating direct Neuro-AI research, life-sciences programs through Radial, and an open-science residency program. svg]:pointer-events-none [&>svg]:size-3 text-foreground [a&]:hover:bg-accent [a&]:hover:text-accent-foreground" href="https://ecosystem.vision/organizations/info/astera-institute~99011485">Company intelligence Emeryville, CA, United States About Astera Institute Astera Institute supports and operates open public-goods work for science and technology. Its current activities include neuroscience-informed AGI research, AI-enabled life-sciences programs, open datasets and publishing infrastructure, and residencies for early-stage projects. svg]:px-3 w-full" data-slot="button" data-variant="secondary" data-size="default" href="/o-astera-institute~99011485">View jobs by Astera Institute Skills BiophysicsComputational BiologyCryo-EmCrystallographyData EngineeringData StandardEnsemble RefinementMachine LearningMetadataProtein DynamicsScientific DatabaseSoftware DevelopmentStructural BiologyUncertainty QuantificationValidation Candidate Availability svg]:pointer-events-none [&>svg]:size-3 [a&]:hover:bg-accent [a&]:hover:text-accent-foreground border-sky-500/20 bg-sky-500/5 text-sky-200 transition-colors cursor-pointer hover:border-sky-400/50 hover:bg-sky-500/15 focus-visible:border-sky-400/50" title="Emeryville HQ">Onsite Emeryville Required Required and preferred rules are kept separate and reflect the wording in the original posting. About The Role You will develop ensemble-aware validation standards and foundational infrastructure for dynamic structural biology data. You will define validation metrics and forward models across crystallography, cryo-EM, and related techniques; guide data deposition, search, and retrieval tools; and translate scientific requirements into robust technical solutions with technical stakeholders. Requirements Ph.D. in structural biology, biophysics, computational biology, or a related fieldDemonstrated expertise in structural biology methodsDeep understanding of structural heterogeneity and dynamics in biomolecular systemsExperience with data standards, metadata frameworks, or scientific database developmentCollaborative skills and ability to build consensus across diverse scientific communities Responsibilities Oversee development of ensemble-aware validation frameworks assessing fit-to-data, physical realism, and uncertainty across structural representationsIdentify and prioritize technical challenges in data representation and validation frameworksGuide creation of data deposition, search, and retrieval tools for structural heterogeneityCoordinate with stakeholders to ensure interoperability and adoptionTranslate scientific requirements into robust technical solutions with software developers, data engineers, and user experience designers