Scientist, Drug Product Development

About the role

NewLimit is seeking a Scientist to join our Delivery Sciences team. This role involves developing formulations, purification processes, and characterization methods for lipid nanoparticle (LNP) drug products. NewLimit’s reprogramming medicines rely on these LNP chemistries to deliver reprogramming payloads to target cells and tissues throughout the body.

Responsibilities

• Formulate, purify, and characterize LNPs for nucleic acid delivery
• Collaborate with the Epigenetic Editing and Product teams (Immunology, Metabolism, Vascular) to develop LNP-RNA reprogramming medicines
• Develop and optimize LNP compositions to target new cell types for reprogramming
• Interpret complex experimental data and perform statistical analyses to reach robust conclusions
• Maintain rigorous and detailed records of experimental protocols and results in an Electronic Laboratory Notebook (ELN)

Requirements

• Ph.D. in Biomedical Engineering, Chemical Biology, Pharmaceutical Sciences, or a related discipline or equivalent industry experience
• Experience formulating LNPs with diverse lipid components for nucleic acid delivery
• Experience with purification techniques, including dialysis, Tangential Flow Filtration (TFF), ultracentrifugation, and sterile filtration
• Proficiency in LNP analysis using dynamic or multi-angle light scattering, liquid chromatography, and standard molecular biology assays (ELISA, qPCR, spectroscopy)

Nice to have

• Experience contributing to drug product development at the preclinical or clinical stages
• Background in extra-hepatic nucleic acid delivery
• Experience with bioconjugation, surface modification, or targeted LNP formulation
• Experience with data visualization and statistical analysis (R, Python)

Benefits

• Comprehensive Health, Dental, and Vision insurance
• 401(k) plan with company match
• Paid parental leave
• Industry-leading PTO: 20 days per year plus holidays
• On-site meals and snacks

Pay

$113,000 to $171,000

Schedule

Full-time