Scientist, Analytical Sciences - LC-MS

We are seeking a Scientist to join our Impurity Characterization team, contributing to the development and implementation of new strategic analytical technologies. This role involves working with single and multidimensional liquid chromatography techniques coupled with mass spectrometry to support impurity characterization of siRNA therapeutics. You will collaborate directly with stability sciences, process development, CMC project management, and various research and early development functions. This is an onsite position primarily located in Cambridge, MA at our Kendall Square offices.

Responsibilities

• Develop, qualify, scale up, and transfer HPLC-based assays for mass and structural identification, characterization, and impurity determination of siRNA therapeutics and their formulations.
• Serve as a subject matter expert (SME) for impurity characterization, understanding all required technical process unit operations and decision-making processes to efficiently support full and targeted impurity characterization for program teams, as well as forced degradation studies for developmental stability.
• Develop new strategies to improve the overall impurity profiling of new development candidates and raw materials.
• Conceive and implement innovative platform improvements by deploying novel workflows to increase operational efficiency through automation.
• Author development reports and regulatory filing documents, and manage analytical activities internally and externally.
• Maintain a current working knowledge of HPLC and MS fundamentals to support troubleshooting of hardware and software.
• Represent the analytical sciences function in cross-functional early-stage development as the analytical development program representative (backup/lead) for early-stage programs.

Qualifications

• Ph.D. in Analytical Chemistry, Biochemistry, or related disciplines with a minimum of 2 years of relevant experience.
• Hands-on experience developing UHPLC-high resolution mass spectrometric methods using design of experiments.
• Experience with oligonucleotide-based LC-assay method development, qualification, transfer, and troubleshooting is strongly preferred.
• Working knowledge of multidimensional LC-MS is strongly preferred.
• Strong documentation and communication skills within the organization and with external partners (contract manufacturing organizations, contract testing labs, external business partners).
• Familiarity with analytical and preparative liquid chromatography hardware and chromatography data software from Waters (Empower, Masslynx, UNIFI) and Agilent (Openlab and Masshunter).

Pay

U.S. pay range: $117,000.00 - $158,200.00 (full-time base salary). Base pay will be determined based on relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Benefits

• Comprehensive medical, dental, and vision coverage.
• Life and disability insurance.
• Lifestyle reimbursement program.
• Flexible spending and health savings accounts.
• 401(k) with a generous company match.
• Paid time off, wellness days, holidays, and two company-wide recharge breaks.
• Generous family resources and leave.

About Alnylam

We are the leader in RNAi therapeutics—a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered breakthroughs that made RNAi therapeutics possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture, and commitment to people. We are a globally recognized top employer with an authentic, inclusive culture where breakthrough thinking fuels progress.