Scientist, ADC Oncology Discovery Biology
About the Role
We are seeking an experienced individual with biologics drug discovery expertise to join the Discovery Biology team within the Oncology Thematic Research Center at Bristol-Myers Squibb in Cambridge, MA. The qualified candidate is a highly motivated, interactive, and creative scientist with the ability to work across a highly matrixed organization to advance programs from target validation to lead optimization, selection of drug candidate, and IND-enabling biology related activities. This individual will be dedicated to designing and executing experimental studies related to the decisional progress of our programs from early stages all the way through IND filing. The candidate will be involved in executing biology bench studies that will advance the understanding of mechanism of action as well as developing several screening funnel assays that will enable compound triaging and identification of potential drug candidate. In addition, the individual will work closely with the informatics and predictive science, translational research, and lead optimization teams to design/execute work related to patient stratification, identification of appropriate in vitro PD markers and assay development/transfer for miniaturization.
Position Responsibilities
- Uses current and new techniques for function-based identification and selection of antibody-drug-conjugate (ADC) lead drug candidates
- Applies extensive technical knowledge to address ADC mechanism of action and to establish PD/efficacy relationships
- Designs and executes molecular and cellular studies
- Collaborates with rest of biology team members as well as other functional area leads e.g. pharmacology, DMPK, informatics and predictive science
- Presents data in lab meetings as well as full team project meetings
- Executes experiments independently, troubleshoot as needed, interpret, and discuss data
- Utilizes excellent communication and interpersonal skills
- Communicates via email, meetings, and reports
- Conducts experimental work independently, with accurate, detailed record-keeping
- Performs laboratory work related but not limited to tissue culture, qPCR, western blot, multi-parametric flow cytometry, immune cell culture using activation/expansion/exhaustion assays, proliferation and tumor killing assays, 2D/3D co-culture activity assays, ELISA, Luminex, processing of DNA/RNA/protein
Qualifications
Basic Qualifications:
- Bachelor's Degree with 5+ years of academic and/or industry experience
- Master's Degree with 3+ years of academic and/or industry experience
- Ph.D. or equivalent advanced degree in the Life Sciences with no experience necessary
Preferred Qualifications:
- Bachelor's/Master's Degree and 1-2 years relevant industry experience
- Experience in oncology and immuno-oncology biologics drug discovery (antibody-drug-conjugates preferred)
- Proficient with expression modulation tools e.g. CRISPRs, shRNAs, siRNAs
- Extensive knowledge of flow cytometry, Incucyte and high content imaging platforms
- Experienced in the design, development and optimization of high-throughput cell-based assays for antibody screening and ADC activity
- Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work
- Ability to summarize and interpret scientific data in a clear, concise, and accurate manner
- Excellent oral and written communication skills. Ability to communicate well with peers and supervisors
- Strong problem-solving skills and understanding of relevant scientific principles
Pay
Cambridge Crossing: $129,640 - $157,096. The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.
Benefits
- Health Coverage: Medical, pharmacy, dental, and vision care
- Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP)
- Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support
- Paid Time Off for US Exempt Employees: Flexible time off (unlimited, with manager approval), 11 paid national holidays
- Paid Time Off for Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
- Based on eligibility, additional time off may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs, and an annual Global Shutdown between Christmas and New Years Day
Schedule
BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
- Site-essential roles require 100% of shifts onsite at your assigned facility
- Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture
- For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function