Scientist 2 - Pharmaceutical Development

About the role

A healthier future drives us to innovate, advance science, and ensure access to healthcare for generations. As part of Pharma Technical Development (PTD), this role contributes to delivering game-changing therapies from clinical phase I to market. The Technical Development Scientist 2 ensures robust clinical and commercial parenteral drug product process designs for effective validation and commercialization, working hands-on at laboratory, pilot plant, and commercial scales.

Key areas include drug product process development, scale-up, technology transfer, and troubleshooting for pharmaceutical processes such as DP liquid filling, prefilled syringes, drying technologies, bulk freezing/thawing, sterile filtration, mixing, and primary container packaging. This role collaborates with formulation scientists, device engineers, and manufacturing staff to support globally harmonized strategy deployment and right-first-time clinical and launch technology transfers.

Responsibilities

• Develop and support Drug Product pharmaceutical processes (e.g., freeze/thaw, mixing, filtration, filling, lyophilization, sterilization).
• Design small-scale models to understand mechanisms and de-risk at-scale processes.
• Collaborate with cross-functional teams, including PTD, Quality, Regulatory, Commercial, and Manufacturing organizations.
• Author, review, and approve internal technical, development, validation, and manufacturing documents (e.g., protocols, reports, exceptions, regulatory filings, SOPs).
• Execute development and qualification studies, technology transfers, and new technology investigations.
• Communicate results and drive projects with project teams and leadership.
• Contribute to assessments of new technologies, patent applications, manuscripts for external publication, and conference presentations.

Requirements

• B.S. in chemical engineering, pharmaceutical sciences, chemistry, bioengineering, or a related discipline with 2+ years of relevant industry experience.
• Ability to translate expertise in chemical engineering, chemistry, and biology into a first-principles understanding of Drug Product processes.
• Hands-on experience with protein processing, lab techniques, and instrumentation.
• Strong analytical and problem-solving skills.
• Excellent written and verbal communication skills; ability to influence in a multidisciplinary setting.
• Knowledge of GMP documentation principles and relevant industry standards/regulatory guidance.
• Ability to contribute to multiple cross-functional projects.

Preferred Qualifications

• Relevant biopharmaceutical industry experience.
• Expertise in process development for large-molecule parenteral Drug Product pharmaceuticals.
• Demonstrated experience implementing processes in clinical or commercial manufacturing facilities.

Pay

The expected salary range for this position in South San Francisco, CA is $92,600 – $172,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors. A discretionary annual bonus may be available based on individual and Company performance.

Benefits

This position qualifies for the comprehensive benefits detailed at Genentech’s benefits page.