Research Scientist/Engr 4

Duties And Responsibilities

• 20% Structure-based and machine-learning immunogen design for protein subunit and mRNA vaccines based on viral surface glycoproteins (construct design, recombinant expression in mammalian cells, purification, and stability assays)
• 20% Characterize protein antigenicity (binding assays using ELISAs, SPR and biolayer interferometry to evaluate binding kinetics and affinity of antibodies or designed proteins)
• 15% Perform structural studies (high-throughput cryo-electron microscopy of subunit vaccines as well as of complexes between viral glycoproteins and monoclonal and polyclonal antibodies as well as X-ray crystallography)
• 10% Design and execution of virology assays
• 10% Analysis of the data to help determine the research strategy
• 10% Lead projects and/or major project tasks
• 10% Interactions with collaborators within our network and writing of manuscripts for publication
• 5% Provide guidance and direction to project staff, students and postdocs

Requirements

Master's Degree in Biochemistry or related field and four years of experience in related field like: Cryo-electron microscopy, virology assays (pseudotyped virus generation, cellular entry and neutralization assays), protein expression in mammalian cells and purification. Equivalent education and/or experience may substitute for minimum qualifications except when there are legal requirements, such as a license, certification, and/or registration.

Desire Expertise in protein and vaccine design, experience in high throughput automation using Beckman Biomek.

About The UW

The University of Washington is committed to fostering an inclusive, respectful and welcoming community for all. As an equal opportunity employer, the University considers applicants for employment without regard to race, color, creed, religion, national origin, citizenship, sex, pregnancy, age, marital status, sexual orientation, gender identity or expression, genetic information, disability, or veteran status consistent with UW Executive Order No. 81.

Applicant Screening

Applicants considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment.