Research Scientist

About the role

Jazz Pharmaceuticals is a global biopharma company dedicated to transforming the lives of patients and their families through innovative medicine. This position is a full-time laboratory-based role focused on designing and executing experiments related to the efficacy and mechanism of action of anticancer compounds, with a specific emphasis on receptor tyrosine kinases (RTKs), particularly HER2.

Responsibilities

• Manage cell culture of cancer and normal cell lines.
• Perform in vitro efficacy, mechanism of action, target validation, and biomarker studies with cancer therapeutics, with an emphasis on RTK/HER2-driven models.
• Create stable cell lines with CRISPR and inducible expression, including lines engineered to modulate RTK/HER2 signaling.
• Create or adapt reporter systems for relevant molecular targets.
• Present summary results for internal communications and external presentations.
• Support preparation of conference abstracts and manuscripts for publication as needed.
• Develop proper operational, data documentation, and troubleshooting procedures.

Requirements

• Three or more years of industry or post-doctoral experience in oncology.
• Demonstrated expertise in receptor tyrosine kinase biology, preferably including HER2, with experience characterizing RTK signaling, pathway modulation, and therapeutic mechanisms of action.
• Experience in oncology and pharmacology assays and techniques.
• Exceptional written and verbal communication including publications and conference presentations.
• Team player who is highly organized and able to manage multiple concurrent projects with minimal oversight.
• Forward-thinking with the ability to anticipate challenges and proactively implement solutions.
• Computer proficient.
• Experience driving advancement of numerous projects simultaneously.
• Able to identify and initiate tasks, set goals for completion, create timelines, and monitor progress to ensure completion.
• Strong sense of urgency to meet business needs.
• A positive, "hands-on" approach to the position.
• Demonstrated ability to react and respond professionally to changing priorities and timelines.
• Demonstrated success in working in a matrix, cross-functional environment.
• Demonstrated ability to communicate clearly both written and oral and work independently with a high level of attention to detail.

Qualifications

• Ph.D. in cancer biology, molecular/cell biology, biochemistry, pharmacology, or related fields, or master’s degree with relevant experience.

Skills

• Ability to perform routine laboratory work, sit or stand at a computer for long stretches of time and type.
• Frequent use of a computer and other office productivity machinery, such as a calculator, copy machine, and computer printer.
• Occasional lifting of objects up to 25 pounds.

Benefits

• Full and complete base pay range: $124,000.00 - $186,000.00
• Discretionary annual cash bonus or incentive compensation (depending on the role).
• Discretionary equity grants in accordance with Jazz's Long Term Equity Incentive Plan.
• Medical, dental, and vision insurance.
• 401(k) retirement savings plan.
• Flexible paid vacation.

Pay

• Base pay range: $124,000.00 - $186,000.00

Schedule

• Full-time position.