Research Scientist

About the role

The candidate must be able to work onsite 5 days a week at Cambridge Crossing. 100% onsite. There is a $20/day parking fee at Cambridge Crossing that is not reimbursed. Position Overview: We are seeking a motivated and talented Scientist to join our Oncology Research and Development team on a 7-months contract basis. This position is heavily focused on wet lab work, contributing to cutting-edge research projects aimed at understanding cancer biology, identifying novel drug targets, and developing new therapeutic approaches. The successful candidate will work in a collaborative and dynamic environment alongside leading scientists in the field of oncology.

Responsibilities

• Conduct full time laboratory-based research supporting target identification, oncology drug discovery and development.
• Execute a variety of molecular biology, cellular biology, and biochemical assays, including:
  • Maintenance and manipulation of 2D and 3D cell cultures, including spheroids and organoids.
  • Lentiviral and nucleofection based gene transfer and genome editing.
  • Target gene perturbation using CRISPR/Cas9 and Cas12, shRNA and siRNA.
  • Cell viability and cytotoxicity assays using IncuCyte, Cell Titer-Glo, Cy QUANT and clonogenic assays.
  • Large scale functional genetic and phenotypic screens.
  • RT-qPCR and western blot, sample prepping for RNA-seq.
  • Co-immunoprecipitation (coIP), and other protein interaction studies.
  • ELISA, Meso Scale Discovery (MSD), and other immunoassays.
  • Design, optimize, and troubleshoot complex cell-based assays to evaluate therapeutic candidates and understand cancer signaling pathways.
• Collaborate with cross-functional teams, including medicinal chemistry, bioinformatics, and in vivo pharmacology, to advance project goals.
• Analyze and interpret experimental data, maintain accurate and detailed lab records, and present findings in team meetings.
• Contribute to the preparation of technical reports, publications, and presentations.

Qualifications

• Bachelors or Masters degree in Biological Sciences, Molecular Biology, Biochemistry, or a related field with extensive and demonstrated track record of experience in conducting oncology research in an academic or industry setting.
• Strong analytical and problem-solving skills, with attention to detail and a capacity to troubleshoot experimental protocols.
• Ability to work independently and as part of a collaborative team.
• Excellent organizational skills, with the ability to manage multiple tasks and deadlines.
• Effective communication skills, both written and verbal.

Preferred Qualifications

• Extensive experience with oncology research, cancer biology, and drug discovery processes.
• Experience with advanced techniques such as high-content imaging and flow cytometry.
• Proficiency in data analysis software (e.g., GraphPad Prism, Flow Jo) and familiarity with bioinformatic tools.