Research Pro 3-Preclinical Research

About The Job

This research position is within the Translational Center for Resuscitative Trauma Care, in the vascular biology laboratory of Dr. Eric Wise. Our mission is to develop and evaluate innovative, effective acute trauma care from point of injury through early post-injury in austere, low resource, rural, and emergency care settings. We also work in understanding the physiology and mechanisms of sepsis in the vasculature.

Responsibilities

• Experimental Research (70%)

• Employ an integrated, translational experimental approach utilizing large animal (porcine) models, rodent models, and cell culture systems, combined with muscle bath, genomic, proteomic, and metabolomic technologies to answer lab-specific questions related to vascular biology, trauma physiology, and sepsis mechanisms.
• Large Animal (Porcine) Studies
• Extensive involvement in large animal (porcine) surgical procedures in an operating room setting, including long, time-sensitive experimental days.
• Manage large animal procedures, including perioperative support, drug administration, and coordination with surgical teams in compliance with IACUC protocols.
• Collect and analyze tissue, blood, and organ samples for downstream molecular and functional analysis.
• Rodent Model Studies
• Conduct rodent surgical procedures and experimental protocols.
• Manage small animal (rodent) procedures, including perioperative care and drug administration in compliance with IACUC protocols.
• Collect and analyze pre-clinical data from rodent models to validate and complement large animal findings.
• Vascular Reactivity and Muscle Bath Systems
• Maintain and utilize muscle/organ bath systems for vascular reactivity studies across human samples, large animal, rodent, and isolated vessel preparations.
• Cell Culture, and Molecular Analysis
• Perform cell culture and molecular and tissue analysis to assess vascular and inflammatory responses, including proteomic analysis, genomic analysis, immunohistochemistry (IHC) and Metabolomic sample preparation.
• Conduct experiments using animal and human samples and associated data.
• Collaboration, Model Development, and Mentorship
• Collaborate with the Experimental Surgery teams.
• Troubleshoot technical and experimental issues in real time.
• Evaluate and optimize new and developing experimental models.
• Able to work in team setup as well as Independently.
• Train and mentor graduate and medical students, ensuring adherence to protocols and safety standards.
• Data Analysis and Management (25%)
• Perform data entry; manage and maintain detailed records of experiments and procedures.
• Generate and disseminate experiment reports to research teams and collaborators.
• Manage sample repository, ensuring proper labeling, storage, and tracking of biological specimens and lab data.
• Additional duties (5%)
• Works under general supervision with ongoing R&D operations as time allows.
• Potential visits to animal lab at USUHS (Washington, DC) and/or Vanderbilt University (Nashville, TN) for training and collaborative studies.
• Participate and Present in Seminars and Nationally Renowned Conferences.

Qualifications

• BA/BS degree plus at least four years of relevant experience, or a combination of education and relevant work experience to equal at least eight years.
• Previous experience in a research setting.
• Must be able to stand at a laboratory bench and Operation Room for extended periods of time and lift up to 40 lbs.
• Must be willing to work in a large animal OR; must have experience in large animal management, including husbandry, drug administration to animals, working with IACUC, and performing procedures.
• Must be willing to take an occasional overnight shift.
• Ideally have supervisory experience in animal management.
• All Required Qualifications must be included in the application materials.

About the Department

The Department is committed to innovation and diversity, educating physicians, scientists, and health professionals; generating knowledge and treatments; and caring for patients and communities with compassion and respect. We value excellence, inclusiveness, collaboration, and discovery. To learn more about the Department of Surgery, please visit https://med.umn.edu/surgery.

Pay And Benefits

Pay Range: $55,390.40-$73,000; depending on education/qualifications/experience
Time Appointment: 100% Appointment
Position Type: Civil-Service & Non-Faculty Labor Represented Staff
Please visit the Office of Human Resources website for more information regarding benefit eligibility.

About University Of Minnesota

The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.