Research Associate, Pre-Clinical Vector Design

About the role

MeiraGTx is a clinical-stage gene therapy company developing next-generation therapies using our highly flexible platform and manufacturing process. The pre-clinical vector design group employs high-throughput screening in disease-relevant models and machine learning to engineer bespoke genetic medicines for diseases of the muscle and central nervous system (CNS).

We are searching for a curious individual who is comfortable multitasking while working on various aspects of our platform. In this role, you will be an essential part of an interdisciplinary team developing and testing the efficacy and safety of these therapeutics in mouse models and iPSCs.

Responsibilities

• Molecular Characterization: Perform routine DNA/RNA extraction from diverse tissues and cells, followed by qPCR/ddPCR for biodistribution and Western Blotting/ELISA for protein expression analysis.
• Cellular Assays: Maintain mammalian cell cultures and perform microscopy and/or flow cytometry to evaluate expression and therapeutic impact in disease-relevant models.
• In Vivo Integration: Support the in vivo team with tissue processing, molecular follow-up, and behavioral assays depending on animal handling proficiency.
• Sequencing Workflows: Prepare NGS libraries for transcriptomic studies to support our machine learning-driven design process.
• Data Processing: Analyze and quantify results using various analytical software (GraphPad Prism, FlowJo, CellProfiler).
• Documentation: Maintain a detailed and accurate electronic lab notebook (Benchling) and present data to the interdisciplinary design team.

Requirements

• B.S. or M.S. in Molecular Biology, Neuroscience, or a related field.
• 1–3 years of laboratory experience in a research or industry setting.

Skills

• Strong proficiency in molecular biology (Western Blotting, ELISA, RNA/DNA isolation, NGS library preparation, and qPCR).
• Strong aseptic technique and mammalian cell culture experience.

Preferred Qualifications

• Basic experience with mouse handling, dosing, or tissue necropsy.
• Familiarity with AAV biology or muscle/CNS disease models.

Benefits

• Contribute to the development of bespoke medicines for CNS and muscle diseases.
• Work within a state-of-the-art platform that merges wet-lab biology with computational machine learning.
• High-impact role with the opportunity to see therapies move from design toward the clinic.