Research Associate II, Preclinical Manufacturing
Responsibilities
- Support the production of RNA cargo molecules and lipid nanoparticle (LNP) formulations for preclinical studies
- Execute hands-on laboratory work involving eRNA synthesis, purification, and LNP encapsulation
- Contribute to the development, optimization, and scale-up of high-yield, high-quality RNA/LNP processes
- Operate and maintain lab-scale instrumentation, including AKTA (FPLC), TFF systems, PCR, HPLC, capillary electrophoresis, UV-Vis, and light scattering platforms
- Analyze experimental data and document results in electronic lab notebooks (ELN) and technical reports
- Collaborate cross-functionally with research, analytical, and process development teams to support project goals
Requirements
- B.S. with 2+ years of industry experience or M.S. in Molecular Biology, Biochemistry, Biochemical Engineering, or a related field
- Hands-on experience in one or more of the following areas: RNA/DNA production and purification, LNP formulation and characterization, Chromatography (e.g., AKTA/FPLC, HPLC), Tangential flow filtration (TFF), Automated liquid handling systems
- Strong understanding of experimental design, data analysis, and technical documentation
- Proficiency in core laboratory techniques, including aseptic technique, buffer preparation, and instrument operation/programming
- Experience with analytical methods such as capillary electrophoresis, UV-Vis, or light scattering is preferred
Qualifications
- Detail-oriented with strong organizational and documentation skills
- Curious, proactive, and comfortable working both independently and in collaborative environments
- Effective communicator with the ability to clearly present technical data and insights
Skills
- Strong laboratory skills and knowledge
- Ability to work independently and as part of a team
- Excellent communication and problem-solving skills
- Knowledge of RNA/DNA production and purification, LNP formulation and characterization, Chromatography, and TFF
Benefits
- Flexible work schedule
- Competitive salary range: $75,000 - $100,000
- Health insurance coverage
- Retirement savings plan
- Professional development opportunities
- Work-life balance initiatives
Pay
- $75,000 - $100,000 annually
Schedule
- Full-time
Benefits
- Health insurance coverage
- Retirement savings plan
- Professional development opportunities
- Work-life balance initiatives
Company Information
Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.
About Sail
Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.