Research Associate II, CRISPR-X - LNP

Responsibilities

• Design, optimize, characterize, and execute lipid nanoparticle (LNP) formulations across a diverse range of lipid compositions and therapeutic payloads with minimal supervision.
• Apply hands-on expertise in LNP analytical characterization techniques, including RiboGreen assays, DLS, NanoFCM, NTA, TFF, endotoxin testing, and HPLC, as well as molecular biology methods such as DNA/RNA extraction, ELISA, SDS-PAGE, PCR, and Western blotting.
• Generate high-quality, reproducible datasets and maintain accurate, detailed experimental documentation in electronic laboratory notebooks (ELNs).
• Perform mammalian cell culture and support in vitro studies, including transient transfection and electroporation in established cell lines.
• Collaborate cross-functionally with process development, analytical, and in vivo teams to support reproducible manufacturing processes and advance programs toward clinical development.
• Contribute to platform innovation by investigating LNP mechanisms of action to improve delivery efficiency, therapeutic potency, and formulation stability.
• Present experimental results, technical findings, and project updates to cross-functional teams and broader organizational audiences.
• Effectively manage multiple priorities and projects in a fast-paced, highly collaborative research environment.

Requirements

• BS or MS in Chemistry, Chemical Engineering, Biochemistry, or a related scientific discipline.
• Relevant industry or academic research experience: Research Associate II: 2-5+ years with a bachelor’s degree or 0-2+ years of relevant experience with a master’s degree.
• Hands-on experience in lipid nanoparticle (LNP) formulation and analytical characterization for nucleic acid and targeted delivery applications.
• Strong understanding of drug delivery systems and gene editing therapeutics.
• Demonstrated ability to work independently while contributing effectively within a fast-paced, results-driven, and collaborative research environment.
• Highly organized with strong scientific rigor, problem-solving skills, and attention to detail.

Qualifications

• Experience with high-throughput formulation screening and knowledge of microfluidic mixing process.
• Prior experience of ionizable lipid design, bioconjugation, and process development preferred.
• Prior experience with scale-up and large-scale manufacturability development of LNPs.
• Understanding of RNA engineering, molecular biology, and hands-on experience of maintaining cells and performing in vitro transfection.