RESEARCH ASSOCIATE I - PROTEOMICS

Sanford Burnham Prebys is a vibrant global community of talented scientists and researchers from over 30 countries, enriching perspectives and enhancing creative approaches to solving complex scientific challenges. Our mission is to advance biomedical sciences by cultivating the next generation of scientific leaders and providing meaningful opportunities for researchers to learn, innovate, and make breakthrough discoveries that improve human health.

About the role

The Sanford Burnham Prebys Medical Discovery Institute (SBP) is seeking a Research Associate I to join its state-of-the-art Proteomics Core Facility. This position involves performing high-quality sample preparation for downstream mass spectrometry-based proteomics analyses. Working under the supervision of the Core Director, the Research Associate I will collaborate with Proteomics Specialists and other Core staff to process biological samples using established and emerging proteomics workflows. The Proteomics Core Facility is equipped with advanced automation systems, including an Agilent AssayMap Bravo, SEER SP100 platform, chromatography systems, and Thermo Fisher Orbitrap mass spectrometers (Orbitrap Fusion Lumos, Q Exactive, Orbitrap Elite, and Quantiva Triple Quadrupole). This role provides an opportunity to contribute to cutting-edge biomedical research and support investigators across diverse scientific disciplines in both academic and industry collaborations. Opportunities for professional development, technical training, and co-authorship on collaborative publications are available.

Responsibilities

• Perform sample preparation for mass spectrometry-based proteomics analyses, including protein extraction, quantification, reduction/alkylation, enzymatic digestion, peptide cleanup, fractionation, enrichment, and other established workflows.
• Operate and maintain automated liquid handling systems (e.g., Agilent AssayMap Bravo, SEER SP100) following established standard operating procedures.
• Prepare reagents, buffers, standards, and quality control samples, ensuring accuracy, consistency, and reproducibility across projects.
• Maintain detailed experimental records, sample tracking, and laboratory documentation in accordance with Core Facility policies and quality standards.
• Perform routine quality control procedures and assist with troubleshooting sample preparation workflows to ensure high-quality downstream mass spectrometry analyses.
• Assist with the routine maintenance, calibration, and organization of laboratory equipment and workspaces; monitor laboratory supplies and coordinate inventory and reagent replenishment.
• Collaborate closely with Proteomics Specialists and Core Facility staff to support diverse research projects from academic and industry investigators.
• Contribute to the development, optimization, and validation of new sample preparation workflows and automation protocols as needed.
• Assist with data organization, preparation of technical summaries, and documentation of experimental results.
• Adhere to institutional safety guidelines, laboratory best practices, and established standard operating procedures.
• Perform other duties as assigned to support the mission and operations of the Proteomics Core Facility.

Requirements

• Bachelor's degree in biology, biochemistry, molecular biology, chemistry, or a related life science field.
• One (1) to three (3) years of relevant laboratory experience in biochemistry, molecular biology, proteomics, or a related discipline; or an equivalent combination of education, training, and/or experience.

Skills

• Experience with protein sample preparation techniques and standard biochemical laboratory methods.
• Working knowledge of techniques such as protein extraction, protein quantification, enzymatic digestion, immunoprecipitation, affinity purification, SDS-PAGE, Western blotting, and protein purification.
• Experience following standard operating procedures (SOPs) with strong attention to detail and reproducibility.
• Ability to maintain accurate laboratory records and manage multiple projects in a fast-paced environment.
• Strong organizational, analytical, and problem-solving skills.
• Excellent verbal and written communication skills and the ability to work collaboratively in a team-oriented, service-focused environment.
• Demonstrated willingness to learn new laboratory techniques and adapt to evolving technologies.
• Strong attention to detail and commitment to producing accurate, reproducible, and high-quality experimental results.
• Excellent organizational and time management skills, with the ability to prioritize and manage multiple projects simultaneously.
• Ability to work independently with minimal supervision while contributing effectively as part of a collaborative team.
• Strong troubleshooting and problem-solving skills, with the ability to identify and resolve routine technical issues.
• Proficiency with Microsoft Office applications (Word, Excel, PowerPoint) and electronic record-keeping systems.
• Ability to maintain a safe, organized, and efficient laboratory environment while adhering to institutional safety policies and regulations.
• Commitment to providing high-quality scientific support and customer service to a diverse research community.

Preferred Qualifications

• Familiarity with mass spectrometry-based proteomics workflows, including LC-MS/MS sample preparation, quantitative proteomics (e.g., TMT or label-free), automated liquid handling systems, Orbitrap mass spectrometry platforms, or proteomics data analysis software (e.g., Proteome Discoverer, MaxQuant, Skyline).

Work Environment

The laboratory is a controlled environment designed to support various scientific activities, equipped with specialized tools and equipment such as microscopes, centrifuges, and incubators. The space adheres to strict safety protocols, with personal protective equipment (PPE) provided and mandatory for all personnel. The atmosphere is collaborative, fostering teamwork and communication among researchers. Workstations are organized for efficiency, with designated areas for sample preparation, analysis, and data management. The laboratory maintains a clean and orderly space, emphasizing hygiene and safety standards. Regular training sessions and meetings are conducted to keep staff updated on best practices and new technologies.

Physical Requirements

• Ability to stand for extended periods and move between different workstations.
• Capability to lift and carry equipment and materials, typically up to 25 pounds, with occasional heavier items.
• Proficiency in using fine motor skills for handling delicate instruments and samples.
• Comfort with repetitive tasks, such as pipetting or using laboratory machinery.
• Ability to distinguish colors and details in specimens and data.
• Flexibility to reach and access equipment or samples stored at various heights.

Pay

The expected hiring range for this position is $22.22–$30.06 per hour.

Schedule

This is an onsite position; candidates must be willing to work onsite in San Diego. Out-of-state applicants must disclose their willingness to relocate.