Research Associate I/II I-O

About the role

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ, specializing in developing innovative cancer treatments using its established drug development platforms. We focus on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). With multiple assets in various stages of clinical trials for solid tumor and hematologic indications, and a robust preclinical pipeline, SystImmune offers an opportunity to learn and grow while making significant contributions to the company’s success.

This role is full-time onsite in Redmond, WA and will move to Bothell, WA in fall 2026.

Responsibilities

• Engineer stable cell lines using lentiviral transduction, CRISPR knock-ins, and knock-outs.
• Analyze complex datasets, prepare technical reports, and present findings to internal teams.
• Perform rigorous batch qualification of critical reagents and cell lines to ensure assay consistency.
• Maintain and manipulate complex co-cultures of primary immune cells and engineered cancer cell lines.
• Conduct functional assays using Incucyte live-cell imaging, flow cytometry, and ELISA-based platforms.
• Develop, optimize, and validate cell-based and immunoassays to support drug development programs.

Requirements

Research Associate I:

• BS or MS in Biology, Immunology, Cell Biology, Bioengineering, Biochemistry, or related scientific field.
• Minimum 1+ year of industry laboratory experience (internships may be considered if highly relevant).
• Hands-on experience with mammalian cell culture techniques and aseptic techniques.
• Exposure to genetic modification workflows such as transient transfections or lentiviral transduction.
• Basic familiarity executing immunoassays such as ELISA or flow cytometry.
• Strong organizational skills and attention to detail.
• Ability to work effectively in a team environment.

Research Associate II:

• BS or MS in a relevant scientific discipline.
• Typically, 2–4 years of relevant industry experience.
• Direct experience engineering cell lines, including executing lentiviral transductions and knock-ins.
• Proven track record executing and troubleshooting cell-based assays and flow cytometry workflows.
• Demonstrated ability to work with moderate independence.

Preferred Qualifications

• Experience supporting oncology, immuno-oncology, immunology, or biologics drug discovery programs.
• Experience with single-cell cloning, CRISPR/Cas9 workflows, or stable cell line selection.
• Proficiency with Incucyte live-cell imaging, multi-color flow cytometry, or MSD multiplex platforms.
• Exposure to high-throughput research settings or regulated laboratory environments.
• Strong data analysis software skills (e.g., GraphPad Prism, FlowJo) and scientific communication skills.

Pay

The expected base salary range for this position is $60,000 - $80,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level, qualifications, experience, and skills.

Benefits

• 100% paid employee premiums for medical, dental, and vision.
• Short-term and long-term disability coverage.
• 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years.
• 15 PTO days per year, sick leave, plus 11 paid holidays.