Research Associate I/II – Clinical Pathology/IHC Biomarker Development
Key Responsibilities
- Perform tissue sectioning of FFPE blocks
- Route and support H&E staining workflows
- Perform routine IHC staining on FFPE tissue specimens using automated platforms (e.g., Ventana, Leica)
- Conduct antibody titrations, protocol optimization, slide preparation, and quality control checks
- Afford assistance in generating feasibility, optimization, and analytical validation data for emerging CDx assays
- Experience with Akoya PhenoImager HT platforms is preferred
Sample & Workflow Support
- Manage tissue samples and associated documentation
- Prepare tissue sections, including slide cutting, baking, antigen retrieval, and reagent preparation
- Maintain sample integrity, traceability, and documentation in compliance with quality system requirements
- Support tissue handling workflows (blocks, slides, labeling, storage) within GLP or CLIA/CAP environments
Data Collection & Documentation
- Accurately record experimental data in ELN and/or LIMS systems
- Capture high-quality slide images and perform basic image analysis
- Afford assist with slide scoring preparation and data summaries
- Summarize experimental findings for internal meetings and assay development reviews
Instrument & Laboratory Maintenance
- Operate, calibrate, and troubleshoot automated IHC staining platforms and related laboratory equipment
- Perform routine instrument maintenance and maintain equipment logs per laboratory quality systems
- Monitor and manage inventory of reagents, antibodies, controls, and consumables
Cross-functional Support
- Collaborate with scientists, pathologists, QA, and clinical development teams on assay transfer, optimization, and validation activities
- Afford support preparation of study materials, controlled documents, and protocol execution for validation studies
Qualifications
- BS or MS in Biology, Molecular Biology, Pathology, Biomedical Sciences, or a related field
- 1–3 years of hands-on experience in histology and/or IHC assay execution within a research or regulated diagnostic laboratory
- Experience handling FFPE tissues and operating automated IHC staining platforms
- Strong attention to detail with excellent documentation and record-keeping practices
- Ability to follow SOPs and work effectively in CLIA-, GxP-, or ISO-regulated environments
Preferred
- Experience supporting IHC assay optimization and/or analytical validation studies
- Exposure to Akoya platforms and multiplex immunofluorescence projects
- Knowledge of antibody characterization and tissue-based biomarker assay development
Compensation and Benefits
The expected base salary range for this position is $60,000 - $80,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s qualifications, experience, and skills. While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.
SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including:
- 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years
- 15 PTO days per year, sick leave, plus 11 paid holidays and MORE
We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.