Research Associate, Clinical Virology

About the role

We are seeking a creative and highly motivated Research Associate to join our Clinical Virology team in South San Francisco. You will work closely with members of the clinical virology team to support antiviral drug discovery and development.

Responsibilities

• Perform testing of clinical isolates to assess viral replication, fitness, and drug susceptibility
• Design and execute in vitro resistance selection experiments
• Characterize resistance-associated substitutions through both phenotypic and genotypic analyses
• Generate and evaluate recombinant viruses carrying clinically relevant mutations
• Perform viral propagation, titration, infectivity, and replication assays
• Conduct nucleic acid extraction, qPCR, RT-qPCR, and related molecular assays
• Collaborate with senior research members and cross-functional teams to analyze data, interpret results, and prepare technical reports and study summaries
• Support multiple projects and learn new techniques to advance novel exploratory discovery work
• Utilize data analysis software and MS Office applications
• Participate in general lab maintenance including reagent preparation, ordering of general lab supplies, and maintenance of equipment

This job description outlines the primary duties and responsibilities of the role; however, it is not intended to be all-inclusive. The scope of responsibilities may be modified, expanded, or adjusted at the discretion of the organization to meet evolving business needs.

Requirements

• B.Sc./M.S. or equivalent degree in Virology, Molecular Biology, Cell Biology, or relevant scientific discipline
• Minimum of 2 - 5 years of relevant experience in industrial or academic settings, preference given to experience in biomarker and translational research activities
• Strong expertise in assay development, virology, cell biology, and molecular biology techniques, e.g. viral stock preparation, titration, and replication assays; in vitro resistance selection; (RT)-PCR, (RT)qPCR; Sanger sequencing and NGS; molecular cloning and mutagenesis; data analysis and visualization
• Comfortable working in a BSL2 setting with potentially infectious agents
• Demonstrated expertise in ensuring good laboratory practices and BSL2 standards
• Ability to present experimental rationale and data to other scientists
• Motivated, proactive molecular virologist and/or cell biologist with a desire to work in a fast-paced, dynamic environment
• Familiarity with Microsoft Office applications, GraphPad Prism, molecular cloning programs, and scientific informatics tools for data input, analysis, and management

Pay

The stated pay range for this position is $87,000 - $91,260 annualized, reflecting the San Francisco Bay Area job market. Assembly Bio establishes pay ranges based on geographic work locations. Additional factors such as academic credentials and relevant experience will influence the actual salary offered.

About Assembly Bio

Assembly Bio (NASDAQ: ASMB) is an ambitious biopharmaceutical company with cutting-edge therapeutic candidates capable of improving the lives of millions living with devastating viral and liver diseases. We have multiple ongoing clinical programs focused on the development of novel treatments for herpesviruses, hepatitis delta virus (HDV), cholestatic liver diseases, and hepatitis B virus (HBV). Our research organization is dedicated to the discovery of new therapies to change the treatment paradigm for individuals living with serious viral and liver diseases.

We pride ourselves on creating a culture and work environment that is scientifically driven, ambitious, and collaborative. We encourage diversity of thought that leads to great innovation and are looking to add great people to our dynamic team who are driven to transform the lives of patients.