Research Associate
University of Pennsylvania · Philadelphia, PA · 2 mo ago
AnalystFull-time
Responsibilities
- Engage in research investigating the role of Ultra-High-Dose Rate ("FLASH") radiotherapy in normal and tumor response in head and neck cancer models.
- Inject HNSCC cells (both HPV+ and HPV-) in the oral cavity of syngeneic mice and irradiate them with Proton FLASH or Standard radiation.
- Assay the impact of these treatments on tumor growth as well as normal tissue toxicity (fibrosis, hyposalivation, atrophy of salivary glands).
- Develop normal tissue and tumor organoids from mouse models and patients with HNSCC.
- Determine the impact of FLASH RT +/- DNA damage repair inhibitors on the therapeutic window using organoids.
- Perform analyses such as scRNAseq and bioinformatics.
- Pertain to the role of Ferroptosis in normal and tumor tissue response to these treatments.
- Write first drafts of manuscripts.
- Apply for funding from several Institutions and foundations, including the NIH, ACS and AACR.
Qualifications
- Expertise in the specific area of Tumor biology, preferably in radiation biology/oncology is required.
- Experience with growing of tissue organoids and performing complex immunohistochemical and immunofluorescence analyses on fixed/embedded tissue is strongly recommended.
- Experience in scRNAseq analysis is a plus.
- A Ph.D. or equivalent degree is required.
- Small animal training certification is required.