Principal Statistical Methodologist

About the role

We are looking for a Principal Statistical Methodologist to join our Statistical Innovation team within Biometric and Data Sciences (BDS), based in Raleigh (US).

Who You Will Work With

You will be part of a team that provides statistical consultancy across therapy areas and development stages, partnering closely with colleagues in clinical development, regulatory strategy, data science, and medical affairs.

What You Will Do

• Provide statistical consultation on clinical trial design and analysis across multiple development stages and therapy areas.
• Develop and implement innovative statistical approaches, including model-based methods using frequentist and Bayesian techniques.
• Run or guide advanced analyses and simulations to inform design options, sample size, and power trade-offs.
• Communicate complex quantitative topics clearly using visuals, simulations, and plain language for diverse audiences.
• Contribute to internal learning by delivering training on advanced statistical concepts for non-statisticians and statisticians.
• Contribute to the group’s external profile through scientific publications, conference presentations, and participation in cross-industry initiatives and working groups.

Requirements

• Doctoral degree in statistics, mathematics, or a closely related scientific discipline.
• 3+ years of experience working in biostatistics within the pharmaceutical industry.
• Experience in statistical methodology for clinical development (early to late stage) is an advantage.
• Expertise in advanced statistical methods and innovative trial design; experience with causal inference and estimands is an advantage.
• Strong statistical programming skills (R preferred; equivalent tools considered).
• Sound knowledge of ICH guidelines and understanding of regulatory requirements from major health authorities.
• Ability to work effectively with autonomy, manage multiple priorities, and deliver timely, high-quality outputs.