Principal/Sr. Principal Scientist - Small Molecule - Lebanon API

About the role

Lilly is seeking a TSMS Principal/Sr Principal Scientist to join the startup team for a new manufacturing facility in Lebanon, IN. This role focuses on process understanding, real-time technical support, and continuous improvement.

Responsibilities

• Apply deep scientific understanding of chemistry, particularly organic chemistry, to support the manufacture of intermediates and APIs.
• Design, interpret, and assess experiments (e.g., laboratory, pilot, or manufacturing-scale studies) and production data to inform process decisions.
• Lead and execute technical projects involving experimental evaluation, modeling concepts, and production data analysis to improve process control, yield, purity, robustness, and productivity.
• Provide real-time technical support during manufacturing activities, serving as a frontline scientific resource for operations and troubleshooting non-routine events.
• Author and maintain technical documentation to support TSMS and API manufacturing, including technical reports, change controls, investigations, validation-related documents, and regulatory support documentation.
• Develop and maintain clear instruction sets (e.g., tickets, procedures, process flow documents) that accurately translate process intent into executable manufacturing guidance.
• Monitor and analyze manufacturing data to assess process variability, capability, and trends, and proactively identify risks or improvement opportunities.
• Participate in and support cross-functional problem-solving, including deviations, investigations, and continuous improvement initiatives related to API manufacturing.
• Communicate effectively with TSMS colleagues, cross-functional partners, and site leadership to ensure shared understanding of process performance, risks, and technical recommendations.

Requirements

• Education Level: Bachelor, Master, or PhD in STEM Discipline (Chemistry preferred)
• Experience: cGMP manufacturing is preferred. A minimum of 3 years of pharmaceutical or fine chemical manufacturing support experience required.

Qualifications

• Basic knowledge in small molecule or peptide.
• Relevant industrial experience in API development and manufacturing.
• Excellent analytical, technical, interpersonal, written, and oral communication skills.
• Ability to work independently and as part of a Process Team.

Skills & Preferences

• Demonstrate basic knowledge in small molecule or peptide.
• Relevant industrial experience in API development and manufacturing.
• Excellent analytical, technical, interpersonal, written, and oral communication skills.
• Ability to work independently and as part of a Process Team.

Benefits

• Eligible for medical, dental, vision and prescription drug benefits.
• Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts).
• Life insurance and death benefits.
• Certain time off and leave of absence benefits.
• Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).

Pay

The anticipated wage for this position is $66,000 - $171,600.

Schedule

8-hour shift, 5 days a week. Night and weekend work possible.