Principal Scientist, Translational Science Immunology

CSL Behring is a global biopharmaceutical leader committed to developing innovative therapies for patients with rare and serious diseases. Our Immunology franchise is advancing a diverse pipeline targeting autoimmune and inflammatory conditions across rheumatology, neuroimmunology, and rare dermatology.

Location: Waltham, MA (hybrid position, three days a week onsite)
Reports to: Senior Director, Translational Research

About the role

You will lead and execute translational research and preclinical development activities to support the Immunology Therapeutic Area Portfolio. This includes designing, planning, executing, and reporting on work-packages related to Pharmacology and Translational Research. The role fosters innovation, maintains CSL’s scientific leadership, and involves collaboration with lab staff, CROs, and internal/external stakeholders.

Responsibilities

• Design and implement in vitro and ex vivo studies to investigate the mechanism of action of lead therapeutic candidates, understand disease patho-mechanisms, and drive target validation activities.
• Design PD response/biomarker strategies and assays to support non-GLP/GLP toxicology studies and first-in-human/early clinical studies, including writing Biomarker Strategy Documents and leading Biomarker Expert Teams.
• Collaborate with Immunology-focused in vivo pharmacology researchers to support indication selection, including writing project proposals, research plans, and research agreements.
• Collaborate with clinical researchers and the clinical development team to provide preclinical studies supporting indication selection and biomarker strategy, including writing project proposals, research plans, human ethics applications, and research agreements.
• Contribute to writing investigator brochures, regulatory submissions, clinical study reports, and other documents to support project progression.
• Work with the Research Therapeutic Area Lead (RTAL) to develop and implement Research Strategy, ensuring alignment with TA priorities.
• Liaise between the Research TA Core team and Translational Research team, along with key internal functions, regarding strategic priorities and project implementation.
• Provide Research input into early-phase NPO due diligence processes.
• Build external scientific and industry networks relevant to the Immunology TA in collaboration with senior management.

Requirements

• PhD in Immunology, Cellular Biology, or a discipline relevant to the Immunology Therapeutic Area.
• 10+ years of academic and/or industry experience in Immunology or immune-mediated diseases.
• Track record in developing and conducting high-quality research relevant to Immunology or immune-mediated diseases.
• Experience translating research outcomes into early clinical development.

Pay

The expected base salary range for this position at hiring is $145,000 - $180,000. Individual base salary is determined by qualifications, skill level, experience, competencies, and other relevant factors. Total compensation may also include incentive compensation and equity.