Principal Scientist/ Senior Principal Scientist, Large Molecule Biology

About the role

Lilly is a global healthcare leader headquartered in Indianapolis, Indiana. We unite caring with discovery to make life better for people around the world. We serve an extraordinary purpose: we make a difference for people around the globe by discovering, developing, and delivering medicines that help them live longer, healthier, more active lives. Beyond breakthrough medicines, we support communities through philanthropy and volunteerism. As a member of Oncology – Large Molecule Biology, you will join a team at the forefront of pharmaceutical science, designing and executing studies that advance portfolio programs with minimal supervision.

Responsibilities

• Design and execute in vitro and ex vivo studies that advance priority oncology targets through the drug discovery pipeline.
• Contribute to multiple programs, develop new methods, and partner across disciplines to inform decisions on therapeutic candidates.
• Execute in vitro pharmacology assays to evaluate tumor cell signaling, antibody binding and internalization, cytotoxicity, effector function, cytokine release, and other cellular responses for medium- and high-throughput drug screening.
• Develop, validate, and run bioanalytical assays and maintain, culture, and passage multiple cell lines to support experimental objectives.
• Conduct multiparameter flow cytometry and other in vitro and ex vivo assays (e.g., receptor occupancy, receptor density, PK/PD, tumor isolation, and blood cell analysis) to characterize binding interactions and cellular responses.
• Oversee experimental work conducted by third-party collaborators and vendors, and partner with project and senior leaders to advance molecules through development.
• Present findings to technical and non-technical stakeholders through preclinical reports, team meetings, and presentations.

Requirements

• B.S. in Biology, Chemistry, Pharmacology or a related field with 5+ years of relevant experience, or an M.S. in Biology, Chemistry, Pharmacology or a related field with 3+ years of relevant experience (role level based on relevant experience).

Qualifications

• Demonstrated expertise in mammalian cell culture techniques.
• Extensive hands-on experience performing in vitro and ex vivo assays.
• Strong understanding of in vitro pharmacology and related data analysis.
• Demonstrated ability to design and execute comprehensive experimental plans on schedule.
• Demonstrated ability to collaborate across scientific disciplines to achieve business objectives.
• Demonstrated excellence in written and verbal communication and interpersonal skills.
• Previous experience with biologic modalities such as monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), and CD3-engaging platforms.
• Proficient in multiparameter flow cytometry, including panel design and data analysis.
• Prior work developing and validating bioanalytical assays.
• Proven ability to independently lead and advance multiple research programs with minimal supervision.
• Track record of managing external collaborations and CRO/vendor relationships.
• Strong record of presenting scientific findings to both technical and non-technical audiences.
• Knowledge of, and strong interest in, cancer disease states (indications, mutational status, tumor cell drivers, etc.).

Skills & Preferences

• Demonstrated expertise in mammalian cell culture techniques.
• Extensive hands-on experience performing in vitro and ex vivo assays.
• Strong understanding of in vitro pharmacology and related data analysis.
• Demonstrated ability to design and execute comprehensive experimental plans on schedule.
• Demonstrated ability to collaborate across scientific disciplines to achieve business objectives.
• Demonstrated excellence in written and verbal communication and interpersonal skills.
• Previous experience with biologic modalities such as monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), and CD3-engaging platforms.
• Proficient in multiparameter flow cytometry, including panel design and data analysis.
• Prior work developing and validating bioanalytical assays.
• Proven ability to independently lead and advance multiple research programs with minimal supervision.
• Track record of managing external collaborations and CRO/vendor relationships.
• Strong record of presenting scientific findings to both technical and non-technical audiences.
• Knowledge of, and strong interest in, cancer disease states (indications, mutational status, tumor cell drivers, etc.).

Benefits

• Eligibility to participate in a company-sponsored 401(k).
• Pension.
• Vacation benefits.
• Medical, dental, vision, and prescription drug benefits.
• Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts).
• Life insurance and death benefits.
• Certain time off and leave of absence benefits.
• Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).

Pay

The anticipated wage for this position is $71,250 - $187,000.

Schedule

Less than 10% travel is expected.