Principal Scientist - Quantitative Translational Scientist

About the role

The Precision Medicine Quantitative Biomarker team (PMQBS) at Regeneron is seeking a Principal Scientist with a blend of deep biomarker and translational-science expertise coupled with advanced computational and analytical skills. This role focuses on exploring and visualizing omics, EHR, wearable sensor, imaging, and other biomarker data, developing tools and dashboards for data querying and cleaning, and providing strategic insights to drive Precision Medicine objectives.

Responsibilities

• Set and refine quantitative biomarker strategies across multiple programs, aligning with Precision Medicine Strategy Leads and senior stakeholders.
• Translate program objectives into testable hypotheses, analytical roadmaps, and decision criteria that inform clinical development and asset strategy.
• Architect exploratory analyses of multi-modal datasets (genomic, transcriptomic, proteomic, metabolomic, clinical, and other biomarkers) to generate actionable insights.
• Define and review statistical frameworks, including hypothesis testing, modeling approaches, and power/sample-size analyses, ensuring appropriate interpretation.
• Oversee the correct application of statistical models on integrated datasets and drive clear, decision-oriented interpretation for translational and clinical teams.
• Contribute to the vision for scalable, reproducible pipelines and automated workflows that support enterprise-wide biomarker discovery and clinical development.
• Direct the design and enhancement of computational workflows for novel biomarkers; evaluate, integrate, or build tools as needed.
• Provide guidance on data cleaning, integration, and visualization standards to enable robust, interpretable analyses.

Requirements

• Proficient in statistical modeling/regression, machine learning, and related data integration/blending techniques.
• Experienced in implementing scalable workflows on cloud platforms (AWS, GCP, or Azure).
• Experienced in Linux and/or cloud environments, shell scripting, and notebook-based workflows.
• Knowledgeable of structured data and data mapping for systems integration, data provisioning, and consumption.
• Experience with version control and AI coding assistants such as Claude.

Qualifications

• Minimum of a PhD with 2 years of relevant industry experience in quantitative fields such as Computer Science, Computational Biology, Systems Biology, Quantitative Biology, Bioinformatics, Data Analytics, Biostatistics.
• A working understanding of Clinical trials is a strong plus.

Skills

• Statistical modeling/regression
• Machine learning
• Data integration/blending
• Cloud platform implementation
• Linux/cloud environments
• Version control
• AI coding assistants

Benefits

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits.

Pay

$128,600.00 - $210,000.00 annually

Schedule

Full time