Principal Scientist, Precision Medicine Strategy Lead (Clinical Biomarkers)
About the role
The successful candidate will define and champion the strategic vision and scientific rationale for clinical biomarker plans supporting multiple clinical stage assets in Regeneron's Immunology & Inflammation (I&I), Ophthalmology, and Infectious Diseases portfolios. They will lead cross-functional teams to design, operationalize, and troubleshoot end-to-end biomarker plans across global studies. They will ensure clinical biomarker assays are fit-for-purpose, whether developed internally or through external collaborators/CROs. They will present translational project plans, biomarker data, and results to internal and external stakeholders, including senior leadership. They will contribute to the highest-quality Precision Medicine content in clinical protocols, study reports, data reviews, biomarker reports, and manuscripts/publications.
Responsibilities
- Define and champion the strategic vision and scientific rationale for clinical biomarker plans supporting one or more programs in I&I, Ophthalmology, and/or Infectious Disease
- Serve as a Precision Medicine representative on clinical development teams, driving biomarker strategy from initial concept through execution, data delivery, and interpretation
- Partner with clinical and laboratory operations to implement biomarker and exploratory sample collection and analyses
- Ensure clinical biomarker assays are fit-for-purpose whether developed internally or through external collaborators/CROs
- Present translational project plans, biomarker data, and results to internal and external stakeholders, including senior leadership
- Contribute to the highest-quality Precision Medicine content in clinical protocols, study reports, data reviews, biomarker reports, and manuscripts/publications
Requirements
- Ph.D. with post-doctoral experience in Immunology or closely related field is highly desirable
- 5+ years of relevant experience in pharmaceutical/biotech industry research and/or translational clinical development
- Exceptional communicator with strong emotional intelligence and enthusiasm for presenting to senior leaders
- Collaborative, innovative, and energized by working in a matrixed environment
- Understanding of biomarker strategy in clinical development, including assay development, validation, and implementation with a track record of high-impact contributions to drug development programs is a huge plus
- Experience authoring industry documents (protocols, CSRs, biomarker reports) is a plus
Qualifications
- Ph.D. with post-doctoral experience in Immunology or closely related field
- 5+ years of relevant experience in pharmaceutical/biotech industry research and/or translational clinical development
Skills
- Translate complex immunology and disease biology into clear, testable clinical biomarker hypotheses and decision criteria
- Lead cross-functional teams to design, operationalize, and troubleshoot end-to-end biomarker plans across global studies
- Drive fit-for-purpose assay development and validation with internal labs and CROs, balancing scientific rigor, cost, and timelines
- Synthesize and communicate biomarker insights into compelling narratives for diverse stakeholders, including senior leadership, to inform key decisions
- Navigate ambiguity, prioritize across multiple programs, and foster a collaborative, innovative culture in a matrixed environment
Benefits
- Competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits
Pay
$128,600.00 - $210,000.00 annually
Schedule
Full time