Principal Scientist, Pharmacokinetics
Merck · Boston, MA · 3 wk ago
Analyst$176k–$277k/yrFull-time
We need to output HTML fragment with sections: About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. Only include sections that have real specific content. Must not repeat job title. Must not include Job ID etc. Must remove boilerplate, navigation, legal, EEO, etc. Must preserve all substantive info.
We need to parse the job description.
Key sections:
- About the role: description of company, role context. Could be first paragraph(s). We'll create a
About the role
with paragraphs summarizing company and role. - Responsibilities: list of primary roles: "Project-team representative and subject matter expert on multiple modality DMPK activities within the oncology and immunology therapeutic areas", "Characterization and optimization of the in vitro and in vivo ADME and pharmacokinetic properties of small molecules and peptide therapeutics", "Design, implementation and analysis of in vitro and in vivo studies to understand the impact of drug disposition on disease biology, pharmacological response (PK/PD) and safety", "Manage a team of lab-based PDMB scientists responsible for developing and executing ligand binding assays and mass spectrometry-based bioanalytical strategies", "Contribute to global DMPK strategy and implementation of cutting-edge ADME science through close collaboration with Discovery and Early Development project teams in Boston (MA), South San Francisco (CA) and West Point (PA) focusing on building highly efficient strategies to identify and optimize drug candidates". Also maybe "Therapeutic area support with focus on our immunology and oncology portfolios, with the potential to contribute to cardiovascular/metabolic, neuroscience and infectious disease efforts as well." That could be part of responsibilities. - Requirements: Education Minimum Requirement: Ph.D (with 6+ years relevant experience) or Master’s (minimum of 10 years relevant experience) degree in biochemistry, chemistry, pharmacology, pharmaceutical sciences, biomedical engineering or related field. Also "Relevant experience to include a record of increasing responsibility and independence in a similar industrial/academic setting". Also "Required Experience And Skills" list: Demonstrated experience leading small molecule, peptide and/or protein therapeutic DMPK discovery efforts as an independent project-team representative within a highly collaborative environment; Ability to design, optimize and interpret DMPK-related optimization strategies (discovery testing funnels) as part of a broader research operating plan; Technical ability to analyze, interpret and provide context around data describing the ADME, pharmacokinetic and pharmacodynamic properties of small molecules, peptides and/or protein therapeutics, including use of software such as Phoenix WinNonlin; Experience contributing to development and execution of translational pharmacokinetic/pharmacodynamic/efficacy relationships and other useful quantitative pharmacology applications in a discovery setting; Proven management experience, including mentorship and talent development of multiple direct reports; Strong leadership, interpersonal, communication, problem solving and collaborative qualities to deliver high quality results in a fast-paced environment. - Qualifications: Might be overlapping with Requirements. Could separate: Education as Qualifications, Experience as Requirements. But we need to follow instruction: Use sections only when posting has real specific content. Could combine Education and Experience under Requirements, and maybe Qualifications for "Preferred Experience And Skills". However they ask for sections: About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. We need to decide what goes where. We have: - About the role: company description and role context. - Responsibilities: bullet list of duties. - Requirements: mandatory education and experience (minimum requirements, required experience and skills). - Qualifications: maybe "Preferred Experience And Skills" and "Preferred Skills" list. - Skills: maybe "Required Skills" list (the bullet list after "Required Skills"). - Benefits: description of benefits package. - Pay: salary range. - Schedule: maybe travel requirements, flexible work arrangements, relocation, visa sponsorship, etc. The posting includes "Relocation: Domestic VISA Sponsorship Yes Travel Requirements 10% Flexible Work Arrangements Not Applicable Shift Not Indicated". So we can include schedule info: Travel 10%, Relocation domestic, Visa sponsorship yes, Flexible work arrangements not applicable, Shift not indicated. We must not include boilerplate like EEO, legal, application instructions, etc. Also must not include duplicated lines. We need to preserve all substantive info. So we need to include the salary range, benefits description, etc. We must not include "Current Employees apply HERE", etc. Also must not include "US And Puerto Rico Residents Only", etc. Also must not include "Search Firm Representatives Please Read Carefully". Also must not include "Employee Status Regular". Also must not include "Job Posting End Date". Also must not include "Requisition ID". Also must not include "EligibleforERP". Also must not include "#EligibleforERP". Also must not include "Current Employees apply HERE Current Contingent Workers apply HERE". Also must not include "We are proud to be a company that embraces the value..." etc (that's EEO boilerplate). Must remove. We need to output only HTML fragment, no markdown fences. Let's craft. Structure:About the role
Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking a dynamic, strategic thinking and collaborative Principal Scientist (director-level equivalent) to contribute to drug discovery and early clinical development efforts. This position will be based at our research labs in Boston, MA. The ideal candidate will lead drug metabolism and pharmacokinetic (DMPK) efforts across multiple modalities (small molecules, peptides, protein therapeutics) as a project-team representative, regularly interacting with multi-disciplinary discovery teams and partners from other functions within our Research & Development Division. Therapeutic area support with focus on our immunology and oncology portfolios, with the potential to contribute to cardiovascular/metabolic, neuroscience and infectious disease efforts as well.
That seems good.Responsibilities
- Project-team representative and subject matter expert on multiple modality DMPK activities within the oncology and immunology therapeutic areas
- Characterization and optimization of the in vitro and in vivo ADME and pharmacokinetic properties of small molecules and peptide therapeutics
- Design, implementation and analysis of in vitro and in vivo studies to understand the impact of drug disposition on disease biology, pharmacological response (PK/PD) and safety
- Manage a team of lab-based PDMB scientists responsible for developing and executing ligand binding assays and mass spectrometry-based bioanalytical strategies
- Contribute to global DMPK strategy and implementation of cutting-edge ADME science through close collaboration with Discovery and Early Development project teams in Boston (MA), South San Francisco (CA) and West Point (PA) focusing on building highly efficient strategies to identify and optimize drug candidates
Requirements
Education: Ph.D (with 6+ years relevant experience) or Master’s (minimum of 10 years relevant experience) degree in biochemistry, chemistry, pharmacology, pharmaceutical sciences, biomedical engineering or related field.
Relevant experience to include a record of increasing responsibility and independence in a similar industrial/academic setting.
- Demonstrated experience leading small molecule, peptide and/or protein therapeutic DMPK discovery efforts as an independent project-team representative within a highly collaborative environment
- Ability to design, optimize and interpret DMPK-related optimization strategies (discovery testing funnels) as part of a broader research operating plan
- Technical ability to analyze, interpret and provide context around data describing the ADME, pharmacokinetic and pharmacodynamic properties of small molecules, peptides and/or protein therapeutics, including use of software such as Phoenix WinNonlin
- Experience contributing to development and execution of translational pharmacokinetic/pharmacodynamic/efficacy relationships and other useful quantitative pharmacology applications in a discovery setting
- Proven management experience, including mentorship and talent development of multiple direct reports
- Strong leadership, interpersonal, communication, problem solving and collaborative qualities to deliver high quality results in a fast-paced environment
Qualifications
- Hands-on experience performing translational pharmacokinetic/pharmacodynamic/efficacy and physiologically-based pharmacokinetic (PBPK) software modeling (e.g., Phoenix WinNonlin, Berkeley Madonna, MATLAB)
- Proven track record supporting immunology or oncology-based programs with experience spanning from early discovery through IND-enabling efforts
- Familiarity with structure-activity relationships aimed at improving pharmacokinetic and pharmacodynamic properties of small molecules or peptides
- Experience working within a research-driven pharmaceutical company
Skills
Required Skills: ADME, Bioanalytical Method Development, Cross-Functional Teamwork, DMPK, Drug Metabolism, Immunology, Oncology, Pharmacokinetics, Pharmacology, PKPD Modeling, Small Molecules, Therapeutic Proteins, Translational Pharmacokinetics and Pharmacodynamics (PKPD)
Benefits
We offer a comprehensive package of benefits including medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
Pay
The salary range for this role is $176,200.00 - $277,300.00. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
Schedule
- Travel Requirements: 10%
- Relocation: Domestic
- VISA Sponsorship: Yes
- Flexible Work Arrangements: Not Applicable
- Shift: Not Indicated