Principal Scientist, LNP Process Development & MS&T

Working with Us

Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Position Summary

The Principal Scientist, LNP Process Development & MS&T plays a central role in enabling the success of batches in clinical development across multiple products. Connecting with both the larger LNP PD team and with research to develop clinical scale batches that are representative across scales and sites. The Principal Scientist is a scientific leader responsible for driving clinical manufacturing strategy, influencing cross-functional decisions, and delivering high-impact outcomes across an increasingly diverse portfolio.

Key Responsibilities

• Scientific Leadership
  Lead the tech transfer from nonclinical production and development to a clinical production site, interfacing with site leadership to ensure clinical production success.
  Provide strategic oversight of process development and manufacturability, while contributing hands-on scientific input where needed to resolve critical technical challenges.
  Apply high throughput data-driven approaches to assess and mitigate risks, defining mitigation strategies and making critical scientific recommendations at key program milestones.
  Represent bulk drug product development strategies in cross-functional CMC teams, ensuring alignment across research, analytical development, engineering, regulatory affairs, and supply chain.

• People Leadership & Talent Development
  Set clear priorities and objectives for LNP PD MSAT in alignment with portfolio goals and LNP PD’s broader organizational strategy.
  Mentor and develop scientists across LNP PD MSAT, contributing to a culture of scientific excellence and continuous learning.
  Foster an inclusive, high-performance team environment built on psychological safety, accountability, and collaboration.

• Innovation & Organizational Contribution
  Propose and lead departmental initiatives that improve scientific workflows, sustainability practices, and operational efficiency.
  Build and maintain collaborative relationships with external academic institutions and industry partners to accelerate scientific advancement.
  Represent capabilities at internal reviews, scientific conferences, and through peer-reviewed publications.

• Cross-Functional Collaboration
  Serve as a key scientific voice in cross-functional CMC teams and broader enterprise forums.
  Partner with functional areas - including research, analytical development, engineering, and drug substance development.
  Collaborate with organization leadership to drive strategic alignment across the portfolio.

Qualifications & Experience

• Degree in Bio/Chemical Engineering, Bio/Chemistry, or related field
  MS with 8+ years’ or PhD with 3+ years’ experience in science related disciplines

• Expertise with lipid nanoparticle formation, conjugation reactions, and tangential flow filtration unit operations
  Working knowledge of statistical design of experiments (DoE) and analysis of multivariate data
  Experience with performing and interpreting process analytics and biophysical characterization techniques such as DLS and Encapsulation Efficiency
  Experience working with both internal and external clinical manufacturing sites
  Knowledge of cGMP, ICH, regulatory guidelines and QbD principles as they apply to risk management and clinical manufacturing

• Exceptional written and oral communication skills, with the ability to convey complex scientific concepts clearly to both technical and non-technical audiences
  Ability to lead complex projects independently and influence decisions across matrixed teams and governance forums
  Prior experience managing, mentoring, or developing scientists in an industrial setting
  Demonstrated background working in a GMP environment and supporting change controls, developing clinical strategies, and resolving deviations in conjunction with Quality teams

• Knowledge of advanced mathematics, nucleic acid chemistry, lipid chemistry, and biology is a plus
  Knowledge of establishing and qualifying scale down models and mechanistic models for process characterization is a plus