Principal Scientist, Large Molecules Mass Spectrometry

About the role

The Bioanalytical Research Group (BAR) at Lilly's research facility in Indianapolis, IN is seeking a strong scientist skilled in protein and oligonucleotide mass spectrometry.

Primary Responsibilities

• Develop and apply QQQ and high-resolution LC/MS approaches to characterize the PK, biotransformation, and biodistribution of therapeutic proteins and new drug modalities in pre-clinical animal models.
• Serve as the bioanalytical representative with project teams to achieve project milestones.
• Prioritize workload and mentor staff scientists within a broad field bioanalytical team.

Job Requirements

• M.S. in biochemistry/molecular biology, bioengineering, biology, pharmacology, chemistry, or equivalent field and 4+ years of work experience (or a B.S. with 6+ years).
• Experience developing and implementing orbitrap mass spectrometry applications to investigate the ADME properties of therapeutic proteins and new modalities (Large Molecules).
• Experience with a wet biochemistry and sample preparation techniques involved in isolating biotherapeutics from biological matrices.

Preferred Qualifications

• Expertise in bioanalysis of siRNA or Antibody-Oligonucleotide Conjugates (AOC).
• Experience assessing PK, Efficacy, and toxicology profiles in preclinical models and presenting data to project teams.
• Knowledge of the ADME principles of biotherapeutic drugs.
• Experience with proteomics methods, DDA, nano-LC, DIA, or similar workflows in a drug discovery setting.
• Additional experience with automation, higher throughput methodologies, and biotransformation software tools.
• Excellent written and verbal communication skills.
• Strong work planning, record keeping and data analysis skills.