Principal Scientist, Integrated Computational and Experimental Inflammation Discovery

About the role

At Amgen, our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With a focus on four therapeutic areas—Oncology, Inflammation, General Medicine, and Rare Disease—we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines.

In this role, you will combine experimental and computational strategies to accelerate discovery and development of innovative therapies. You will bring deep expertise across wet-lab biology and AI/ML-driven computational and agentic research approaches, enabling human-data-driven understanding of disease mechanisms and therapeutic opportunities.

Responsibilities

• Continuously apply computational, agentic, and other AI-driven approaches to generate mechanistic insights, refine therapeutic hypotheses, and guide experimental design.
• Design, execute, analyze, and interpret studies to investigate disease mechanisms and test therapeutic hypotheses.
• Generate high-quality experimental data to support target identification, validation, and progression of Inflammation research programs.
• Integrate experimental findings with published literature, human genetics, clinical observations, and other data sources to develop mechanistic insights and inform scientific decision-making.
• Participate in scientific discussions, target reviews, and portfolio evaluations by contributing data-driven insights and recommendations.
• Present scientific findings and recommendations to project teams, governance forums, and departmental meetings.
• Maintain accurate documentation and contribute to organizational knowledge-sharing efforts.
• Embrace and contribute to a culture of scientific curiosity, collaboration, continuous learning, and operational excellence.

Qualifications

Basic Qualifications

• Doctorate degree (PhD, PharmD, or MD) and 2 years of industry experience in Inflammation/Immunology research (including relevant post-doc where applicable), or
• Master’s degree and 5 years of industry experience in Inflammation/Immunology research, or
• Bachelor’s degree and 7 years of industry experience in Inflammation/Immunology research.

Preferred Qualifications

• Experience working effectively within highly collaborative and matrixed research environments.
• Ability to balance scientific rigor with urgency and adaptability in a dynamic research environment.
• Demonstrated commitment to teamwork, knowledge sharing, and continuous improvement.

Benefits

Amgen offers a comprehensive employee benefits package, including:

• A Retirement and Savings Plan with generous company contributions.
• Group medical, dental, and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program (or sales-based incentive plan for field sales representatives).
• Stock-based long-term incentives.
• Award-winning time-off plans.
• Flexible work models where possible.

Pay

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to relevant skills, experience, and qualifications.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.