Principal Scientist, Early Pipeline Development

About the Role

We are seeking a highly motivated Principal Scientist I with extensive AAV gene therapy manufacturing experience to develop state-of-the-art downstream purification processes for next-generation AAV gene therapy. This role focuses on early-stage process development, emphasizing the developability of AAV gene therapy lead candidates, as well as new platform process development for existing and novel AAV capsids and cargo vectors.

Responsibilities

• Lead and manage a 3-5 person downstream process team and provide technical support, training, and subject matter expertise to assist with the professional development of direct reports.
• Coordinate activities with associates across upstream process and analytical teams.
• Develop strategies in collaboration with Disease Areas and partner with various line functions to support early drug discovery from target selection and validation through lead compound selection and developability assessment.
• Serve as a subject matter expert to transfer manufacturing process knowledge to the Technical Research & Development team and advance pipeline programs into clinical phases.
• Lead efforts and work collaboratively with Technical Research & Development to develop innovative and cost-effective downstream processes for next-generation AAV.
• Manage multiple project workflows to ensure timely delivery.
• Prepare written reports conforming to defined documentation practices, including electronic lab notebooks.
• Perform other related duties as assigned.

Requirements

• PhD in bioprocessing, biochemical engineering, gene therapy, or a related field with 3+ years of relevant process development experience in a biotechnology/pharmaceutical environment.
• Experience in people management.
• Knowledge of downstream purification processes, including affinity and ion-exchange chromatography, with hands-on experience using AKTA purification systems.
• Technical proficiency, creativity, and independent thought.
• Effective communication skills to convey scientific concepts to research scientists and cross-functional collaborators.
• Strong organization and problem-solving skills with attention to detail.
• Ability to work in a fast-paced and matrix environment.

Qualifications

• Experience in AAV gene therapy (desired).
• Experience with viral gene therapy (desired).

Pay

The salary for this position is expected to range between $108,500 and $201,500 per year for Principal Scientist I, and between $119,700 and $222,300 per year for Principal Scientist II. The final salary offered is determined based on factors such as relevant skills and experience. Compensation includes a performance-based cash incentive and eligibility for annual equity awards.

Benefits

• Comprehensive health, life, and disability benefits.
• 401(k) with company contribution and match.
• Generous time off package, including vacation, personal days, holidays, and other leaves.