Principal Scientist, Drug Product Development

Key Responsibilities

• Lead formulation development for peptide therapeutics across parenteral (SC/IV/IM), oral, and advanced delivery systems (e.g., nanoparticles, depot formulations)
• Design and optimize dosage forms including injectables, tablets, capsules, and enabling delivery technologies
• Evaluate and implement high concentration peptide formulation, incorporating sustained release, absorption enhancement, and stabilization strategies
• Design and interpret biorelevant in vitro and in vivo studies to support PK/PD and candidate selection
• Contribute to CMC development from early feasibility through IND-enabling and clinical stages
• Support technology transfer, scale-up, and external manufacturing (CRO/CDMO) activities
• Collaborate cross-functionally with DMPK, biology, analytical, and regulatory teams
• Provide technical leadership and mentorship within Pharmaceutical Sciences

Qualifications

• PhD in Pharmaceutics, Pharmaceutical Sciences, Chemical Engineering, Chemistry, or related field
• 8-10+ years of industry experience in drug product development for peptides and/or biologics
• Demonstrated expertise in multiple formulation modalities, including parenteral formulations (SC/IV/IM), and oral dosage forms
• Experience in advanced delivery systems (e.g., nanoparticles, depot formulations) is a plus
• Strong understanding of biopharmaceutics, stability, release/absorption and in vitro–in vivo translation
• Experience contributing to IND/CTA-enabling CMC activities
• Experience with late-stage or commercial formulations is highly desirable
• Experience working with and managing CRO/CDMO partners
• Strong scientific judgment, problem-solving skills, and communication