Principal Scientist - Cancer Vaccines

About the role

Lead ICR's Cancer Prevention Group in researching and developing novel preventive cancer vaccines. Drive end-to-end design, execution and interpretation of preclinical vaccine studies, directly shaping the path to human translation. Collaborate closely with external KOLs and CRO partners to turn cutting-edge cancer immunology insights into first-in-class preventive vaccine programs.

Responsibilities

• Lead research and development of novel preventive cancer vaccines
• Design, execute, and interpret preclinical vaccine studies
• Collaborate with external KOLs and CRO partners
• Derive antigen-specific T cell clones and lines
• Work with molecular T cell receptor repertoire analysis and tracking, T cell proliferation assays, cytokine release assays and ELISPOT
• Experience with vaccine delivery systems, including peptide-, cell- and viral-based systems
• Manage external projects

Requirements

• A PhD, MD or both and at least 10 years of vaccine development experience, preferably cancer vaccines
• In-depth knowledge of and experience researching personalized cancer vaccines, including peptide-based vaccines and neoantigen-based cancer vaccines
• Extensive experience with vaccine epitope identification, selection/prioritization (of neoantigens), vaccine adjuvants and immune response monitoring
• Expertise in cancer stem cell antigens, tumor-associated antigens, neoantigens, immuno-editing and immuno-monitoring
• The ability to work well with CROs

Qualifications

• The ability to work in the United States without sponsorship
• An easygoing, hard-working personality

Skills

• Knowledge of and experience with vaccine epitope identification, selection/prioritization (of neoantigens)
• Experience with molecular T cell receptor repertoire analysis and tracking
• Experience with T cell proliferation assays, cytokine release assays and ELISPOT
• Experience deriving antigen-specific T cell clones and lines
• Expertise in cancer stem cell antigens, tumor-associated antigens, neoantigens, immuno-editing and immuno-monitoring
• Experience with vaccine delivery systems, including peptide-, cell- and viral-based systems
• The ability to work well with CROs and manage external projects

Benefits

• Starting base pay range: $165,000/yr - $215,000/yr
• Starting additional compensation range: $7,500/yr - $20,000/yr

Pay

• Starting base pay range: $165,000/yr - $215,000/yr

Schedule

• Full time