Principal Scientist Biophysical Characterization

About the role

Verve Therapeutics, a wholly owned subsidiary of Eli Lilly & Company within Lilly Research Labs, is seeking an Analytical Development Scientist to join our growing team. This role is part of a Technical Operations team that partners closely with Quality Control, Quality Assurance, Process Development, and Analytical Research & Development.

Responsibilities

• Develop, optimize, and execute analytical methods intended for a variety of purposes, including release and stability testing, product characterization, high-throughput analysis, and characterization of complex raw materials.
• Collect, process, and analyze experimental data and information applying HPLC, UHPLC, capillary electrophoresis, LCMS, MALS and/or other instrumental analysis techniques, ensuring accurate and timely documentation in electronic laboratory notebook.
• Review, interpret, and present data within the analytical team and cross-functionally.
• Author, review, and revise technical source documents to support phase-appropriate comparability.
• Provide technical oversight to guide analytical/QC investigations, as needed.
• Actively collaborate with internal and external process development and quality teams.
• Train and mentor junior team members.

Requirements

• MS in analytical chemistry, biochemistry, biophysics or a related field with 4+ years of experience in Biotech or Biopharmaceutical industry OR BS in analytical chemistry, biochemistry, biophysics or a related field with 6+ years of experience in Biotech or Biopharmaceutical industry
• Minimum of 3 years of experience in LC and CE assay development required
• Hands-on experience developing, qualifying and troubleshooting biophysical assays using HPLC/UPLC, LCMS and capillary electrophoresis (CE).

Basic Requirements

• Strong technical background on analytical methodologies using CE and HPLC for gRNA, mRNA, LNPs.
• Experience in method transfer, validation, and implementation to support target candidate validation from non-GxP to GMP environments.
• Familiarity with applicable ICH regulations related to method validation.

Additional Preferences

• Proactive, creative, and positive attitude.
• Effective oral and written communication skills.