Principal Scientist, Biology (Immunology)

About C4 Therapeutics

C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transforms patients' lives. C4T is progressing targeted oncology programs through clinical studies and leveraging its TORPEDO® platform to efficiently design and optimize small-molecule medicines to address difficult-to-treat diseases. C4T's degrader medicines are designed to harness the body's natural protein recycling system to rapidly degrade disease-causing proteins, offering the potential to overcome drug resistance, drug undruggable targets and improve patient outcomes. For more information, please visit www.c4therapeutics.com.

Job Summary

C4 Therapeutics is seeking a highly motivated and innovative Principal Scientist in Immunology to lead discovery and translational research for autoimmune and inflammatory diseases within our targeted protein degradation (TPD) platform.

• Drive mechanism-based therapeutic strategies, advancing degrader programs from target identification through IND-enabling studies, with a strong emphasis on human biology, immune modulation, and translational relevance.
• Operate at the intersection of immunology, chemical biology, and drug discovery, contributing to a high-impact pipeline addressing significant unmet needs in inflammatory and autoimmune diseases.
• Use your strong critical-thinking skills to independently design, execute, troubleshoot, and analyze experiments in our exciting fast-paced environment.
• Contribute meaningfully to your projects, propose and explore new ideas, and adapt and pivot to follow the latest cutting-edge innovations in the immunology field.

Your Role:

• Lead one or more autoimmune-focused discovery programs, from target identification through candidate selection, including experimental strategy and milestones to generate robust translational data packages and support progression toward development.
• Integrate biology, pharmacology, and chemistry data to enable data-driven decisions and portfolio prioritization.
• Identify and validate novel targets and pathways driving autoimmune disease biology, maintaining deep awareness of emerging trends in immunology and autoimmune disease biology.
• Design and execute in vitro, ex vivo, and in vivo studies to support validation and differentiation of degraders as well as their mechanism of action.
• Collaborate closely with team members within and across functional areas to achieve key company goals.
• Analyze, summarize, and present data at team meetings and broader project team meetings.
• Build and manage academic and industry collaborations.
• Mentor/develop junior scientists and provide technical leadership and foster a culture of scientific rigor and innovation.

Your Background:

• A Ph.D. in Immunology, Cell Biology, or related discipline with a minimum of ten years of industry experience in biotechnology or pharmaceutical drug discovery.
• Demonstrated success leading autoimmune or inflammatory disease programs.
• Deep expertise in immune cell biology (e.g., T cells, myeloid cells, immune regulation), inflammatory/autoimmune disorders, and cellular and molecular assay design.
• Strong record of scientific achievement (publications, patents, or pipeline contributions).

Preferred:

• Experience in CRO management.
• Experience with targeted protein degradation.
• Experience developing human-relevant translational models (ex vivo systems, patient-derived samples, or complex immune assays).

Compensation

The base pay range for this position at commencement of employment is expected to be between $187,632.00 and $207,383.00 annually; however, base pay offered may vary depending on multiple individualized factors, including job-related knowledge, skills, and experience.

C4 Therapeutics is an Equal Opportunity Employer.