Principal Scientist
Sanofi · Waltham, MA · 6 days ago
HybridInformation TechnologyFull-time
About the role
The Genomic Medicine Unit (GMU) CMC group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant AAV vectors, lentiviral vectors and cell therapy products. Sanofi is looking for an experienced cell culture development professional with experience in cell therapy process development to join the Genomic Medicine Cell Therapy Process Development Group located in Waltham, MA in the role of Senior Scientist.
Main responsibilities
- Lead scale-up activities from bench scale to pilot scale (200L–2000L), applying engineering principles (mixing, mass transfer, shear stress, dissolved oxygen control) to ensure process comparability at large scale.
- Collaborate with process development scientists to translate laboratory findings into scalable, robust manufacturing processes.
- Review and approve JSAs written by equipment owners and provide feedback.
- Train employees to adopt best practice for safety, efficiency and operational success.
- Build robust internal interfaces with the CMC community and promote the adoption of best practices.
- Demonstrate expertise in upstream process operations at all scales.
- Lead root cause analysis (RCA) investigations for process deviations, equipment failures at pilot scale.
- Present findings and/or results to senior management, external stakeholders, and industry leaders at national/international conferences.
About You
- Master’s degree in Chemical Engineering, or related discipline with a minimum of 6 years of relevant experience to large-scale bioreactors, or a Ph.D degree with a minimum of 4 years of industry experience related to large-scale bioreactors.
- Strong background in cell culture bioreactor operations and scale-up technologies.
- Experience in the biotech/pharmaceutical industry within a cell culture role and an excellent understanding of the operational excellence.
- Experience with perfusion process operations at various scales.
- Understanding of engineering principles related to cell culture process is required.
- Ability to lead matrix teams for operations and lab management.
Preferred Qualifications
- Experience managing cross-functional team and initiatives.
- Experience in cell culture process development for AAV manufacturing.
- Expertise in mammalian cell culture and related aspects such as cell metabolism/media optimization, engineering fundamentals on cell culture scale-up/down, cell biology/physiology.
- Process automation experience.
About Sanofi
We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.
Why Choose Us
- Bring the miracles of science to life alongside a supportive, future-focused team.
- Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
- Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
- Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
- Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.
- Help improve the lives of millions of people globally by making drug development quicker and more effective.
- Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.