Principal Research Scientist II, Lipid Chemistry

About the role

We seek a Principal Scientist II, Lipid Chemistry to join an experienced, fast-paced and collaborative team focused on developing lipid nanoparticle delivered mRNA medicine. This position will lead the design and synthesis of novel lipids including but not limited to ionizable lipids and other proprietary delivery chemistries.

Responsibilities & Duties

• Lead and optimize novel lipid designs and chemistries from diverse structural families for LNP platform technology development
• Plan and execute efficient synthetic routes for target molecules and close analogs. Optimize reactions, troubleshoot challenging transformations, and solve synthetic bottlenecks.
• Design multistep routes of synthesis and purification for scalability and purity in keeping with project goals and timelines. Generate focused analog libraries to explore structure-activity relationships and guide design decisions.
• Independently lead research efforts through deep technical understanding and work collaboratively within a cross-functional product development team to drive design, functional screening, development and production of novel tLNP formulations for targeted, extra hepatic delivery of nucleic acid payloads.
• Review scientific literature, patents, scientific abstracts to stay up to date on latest in the field. Provide scientific expertise in the organization with special emphasis on lipid nanoparticle-based drug targeting delivery systems for nucleic acids
• Represent department in cross-functional platforms, pipeline and development teams. Collaborate with cross-functional discovery teams to translate in vitro and in vivo experimental findings into improved molecular designs.
• Present synthetic strategies, experimental results, and SAR insights clearly and concisely.
• Effectively communicate complex technical topics to collaborators and management. Present synthetic strategies, experimental results, and SAR insights clearly and concisely.

Qualifications

• Bachelor’s Degree in Science related field with 16 years of related work; Masters Degree Science or PharmD with 14 years of related work; PhD in Science or related field with 8 years of related work experience.
• Experience in the pharmaceutical industry for which you have been responsible for independent contributions in the design and development of novel lipids and other delivery chemistries
• Demonstrated deep expertise in synthetic organic chemistry with a strong publication or industry record.
• Deep technical prowess and demonstrated ability with respect to successful design, synthetic routes, purification strategies, analytical characterization (e.g. NMR, LC/MS) for lipids and LNP formulations.
• Extensive experience in advanced route design, synthesis planning, and execution of complex multi-step syntheses.
• Strong problem-solving skills in synthesis, including reaction development, optimization, and troubleshooting.
• Strong proficiency authoring and reviewing technical reports.