Principal Research Scientist I, siRNA Platform Automation

About the role

The Principal Research Scientist I, siRNA Platform Automation, will lead the development and implementation of a high-throughput siRNA screening platform. This role involves partnering with genetic medicine teams to advance pipeline innovation through next-generation delivery modalities and supporting the discovery of therapeutic leads across multiple disease areas.

Responsibilities

• Establish and implement a high-throughput siRNA screening platform using automated liquid-handling systems.
• Serve as a subject matter expert in siRNA screening experimental design, execution, and data interpretation.
• Lead research efforts and mentor scientists to advance siRNA optimization, including sequence design and novel chemical modifications, across multiple programs.
• Generate new scientific hypotheses and proposals, improve existing screening workflows, and evaluate emerging technologies in the siRNA field.
• Communicate clearly and effectively with internal siRNA teams and cross-functional collaborators to identify needs and support platform enhancement and program advancement.
• Manage and develop a team of at least 2-3 scientists, providing technical guidance, mentorship, and day-to-day leadership to support program goals.

Requirements

• BS, MS, or PhD in Molecular Biology, Biochemistry, Chemical Biology, or a related field, with typically 6+ years (PhD), 12+ years (MS), or 14+ years (BS) of relevant experience in biotech or pharma.
• Proven track record in siRNA design, in vitro screening, and potency assays with experience using automated high-throughput platforms (e.g., Hamilton, Tecan).
• Experience with assays including, but not limited to, qRT-PCR, ELISA, and flow cytometry.
• Demonstrated experience in cell culture, including the maintenance of diverse cell lines.
• Prior experience leading siRNA platform initiatives or portfolio programs.
• Experience in animal study design and downstream assays to evaluate genetic medicines is a plus.
• Exceptional interpersonal skills and the ability to build productive working relationships with diverse internal teams and external collaborators.
• Strong track record of presenting complex scientific data to internal and external stakeholders.
• Prior people management experience is a plus.

Qualifications

• BS, MS, or PhD in Molecular Biology, Biochemistry, Chemical Biology, or a related field, with typically 6+ years (PhD), 12+ years (MS), or 14+ years (BS) of relevant experience in biotech or pharma.

Skills

• Proven track record in siRNA design, in vitro screening, and potency assays with experience using automated high-throughput platforms (e.g., Hamilton, Tecan).
• Experience with assays including, but not limited to, qRT-PCR, ELISA, and flow cytometry.
• Demonstrated experience in cell culture, including the maintenance of diverse cell lines.
• Prior experience leading siRNA platform initiatives or portfolio programs.
• Experience in animal study design and downstream assays to evaluate genetic medicines is a plus.
• Exceptional interpersonal skills and the ability to build productive working relationships with diverse internal teams and external collaborators.
• Strong track record of presenting complex scientific data to internal and external stakeholders.
• Prior people management experience is a plus.

Benefits

• Comprehensive benefits package including paid time off, medical/dental/vision insurance, and 401(k).
• Participation in short-term and long-term incentive programs.

Pay

$124,500 - $236,500 USD

Schedule

On-site, full-time